Gonadotrop releasing hormon (Gn-RH) analóg alkalmazása emlörák betegségben.

Translated title of the contribution: Therapeutic use of a gonadotropin releasing hormone analogue in breast cancer

Research output: Contribution to journalArticle

Abstract

Superagonistic analogues of Gn-RH given chronically produce a paradoxic inhibition of pituitary gonadotropin secretion and consequently decrease the peripheric hormones estradiol and progesterone to a postmenopausal level. For curative purposes buserelin (SuprefactR, Hoechst) treatment has been performed by the authors in two cases of breast cancer. The patients--one with NED (no evidence of disease) and the other with pulmonary and osseal metastases--in addition to low hormonal levels developed amenorrhoea. A group of climacteric complaints were observed without any toxic side effects, however. The treatment of premenopausal women suffering from breast cancer with chronic administration of Gn-RH analogues may constitute a valuable alternative to surgical oophorectomy.

Original languageHungarian
Pages (from-to)1033-1036
Number of pages4
JournalOrvosi Hetilap
Volume131
Issue number19
Publication statusPublished - May 13 1990

Fingerprint

Therapeutic Uses
Gonadotropin-Releasing Hormone
Buserelin
Breast Neoplasms
Pituitary Gonadotropins
Poisons
Amenorrhea
Ovariectomy
Progesterone
Estradiol
Hormones
Neoplasm Metastasis
Lung
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gonadotrop releasing hormon (Gn-RH) analóg alkalmazása emlörák betegségben. / Kahán, Z.; Falkay, G.

In: Orvosi Hetilap, Vol. 131, No. 19, 13.05.1990, p. 1033-1036.

Research output: Contribution to journalArticle

@article{8996505e2534484685fb4d78c41aec5b,
title = "Gonadotrop releasing hormon (Gn-RH) anal{\'o}g alkalmaz{\'a}sa eml{\"o}r{\'a}k betegs{\'e}gben.",
abstract = "Superagonistic analogues of Gn-RH given chronically produce a paradoxic inhibition of pituitary gonadotropin secretion and consequently decrease the peripheric hormones estradiol and progesterone to a postmenopausal level. For curative purposes buserelin (SuprefactR, Hoechst) treatment has been performed by the authors in two cases of breast cancer. The patients--one with NED (no evidence of disease) and the other with pulmonary and osseal metastases--in addition to low hormonal levels developed amenorrhoea. A group of climacteric complaints were observed without any toxic side effects, however. The treatment of premenopausal women suffering from breast cancer with chronic administration of Gn-RH analogues may constitute a valuable alternative to surgical oophorectomy.",
author = "Z. Kah{\'a}n and G. Falkay",
year = "1990",
month = "5",
day = "13",
language = "Hungarian",
volume = "131",
pages = "1033--1036",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "19",

}

TY - JOUR

T1 - Gonadotrop releasing hormon (Gn-RH) analóg alkalmazása emlörák betegségben.

AU - Kahán, Z.

AU - Falkay, G.

PY - 1990/5/13

Y1 - 1990/5/13

N2 - Superagonistic analogues of Gn-RH given chronically produce a paradoxic inhibition of pituitary gonadotropin secretion and consequently decrease the peripheric hormones estradiol and progesterone to a postmenopausal level. For curative purposes buserelin (SuprefactR, Hoechst) treatment has been performed by the authors in two cases of breast cancer. The patients--one with NED (no evidence of disease) and the other with pulmonary and osseal metastases--in addition to low hormonal levels developed amenorrhoea. A group of climacteric complaints were observed without any toxic side effects, however. The treatment of premenopausal women suffering from breast cancer with chronic administration of Gn-RH analogues may constitute a valuable alternative to surgical oophorectomy.

AB - Superagonistic analogues of Gn-RH given chronically produce a paradoxic inhibition of pituitary gonadotropin secretion and consequently decrease the peripheric hormones estradiol and progesterone to a postmenopausal level. For curative purposes buserelin (SuprefactR, Hoechst) treatment has been performed by the authors in two cases of breast cancer. The patients--one with NED (no evidence of disease) and the other with pulmonary and osseal metastases--in addition to low hormonal levels developed amenorrhoea. A group of climacteric complaints were observed without any toxic side effects, however. The treatment of premenopausal women suffering from breast cancer with chronic administration of Gn-RH analogues may constitute a valuable alternative to surgical oophorectomy.

UR - http://www.scopus.com/inward/record.url?scp=18744429961&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18744429961&partnerID=8YFLogxK

M3 - Article

C2 - 2111904

AN - SCOPUS:18744429961

VL - 131

SP - 1033

EP - 1036

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 19

ER -