A koponyasérülés által kiváltott axonkárosodás és kezelésének lehetóségei.

Translated title of the contribution: Therapeutic possibilities in axonal injury caused by head trauma

A. Büki, O. Farkas, Ferenc Kövér, T. Dóczi

Research output: Contribution to journalArticle

Abstract

Traumatic brain injury is putting an extreme burden on societies all over the world. While surgical and neuro-intensive treatment is traditionally aimed at space occupying or focal lesions, traumatic brain injury is frequently associated with diffuse axonal injury, which significantly contributes to its morbidity and mortality. Current taught appreciates that diffuse axonal injury is a progressive event gradually evolving from focal alterations in axolemmal permeability and the underlying axonal ultrastructure to axonal disconnection, a process amenable of therapeutic interventions. This review is primarily focusing on the clinical/neuroradiological manifestation and our contemporary knowledge of the pathobiology of traumatically evoked (diffuse-) axonal injury with particular emphasize on recent- to date, primarily experimental-therapeutic approaches that in the future might offer potential aid to the head injured.

Original languageHungarian
Pages (from-to)499-503
Number of pages5
JournalOrvosi Hetilap
Volume143
Issue number10
Publication statusPublished - Mar 10 2002

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Diffuse Axonal Injury
Craniocerebral Trauma
Wounds and Injuries
Permeability
Therapeutics
Head
Morbidity
Mortality
Traumatic Brain Injury

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A koponyasérülés által kiváltott axonkárosodás és kezelésének lehetóségei. / Büki, A.; Farkas, O.; Kövér, Ferenc; Dóczi, T.

In: Orvosi Hetilap, Vol. 143, No. 10, 10.03.2002, p. 499-503.

Research output: Contribution to journalArticle

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