Theoretical characterization of gas-liquid chromatographic stationary phases with quantum chemical descriptors

Eufrozina A. Hoffmann, Zoltan A. Fekete, Robert Rajkó, István Pálinkó, Tamás Körtvélyesi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Quantitative structure-property relationship (QSPR) solvent model has been developed for the McReynolds constants (prototypical solutes) on 36 gas-liquid chromatographic stationary phases. PM6 semiempirical quantum chemical calculations combined with conductor-like screening model (COSMO) has been utilized. From 276 descriptors considered, forward stepwise variable selection, followed by best subset selection, yielded linear regression models containing six purely quantum chemical and two hybrid, topologically based descriptors. Internal (leave-one-out and bootstrap) as well as external validation methods confirmed the predictive power of these structure-driven models across all 10 McReynolds constants, with 40 Kováts-index units overall root-mean-square prediction error estimate.

Original languageEnglish
Pages (from-to)2540-2547
Number of pages8
JournalJournal of Chromatography A
Volume1216
Issue number12
DOIs
Publication statusPublished - Mar 20 2009

Keywords

  • Chemometrics
  • McReynolds constants
  • QSPR
  • Quantum chemical
  • Semiempirical
  • Stationary phase

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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