Theophylline concentrations in serum, saliva, and cerebrospinal fluid in patients with essential tremor

J. Málly, C. S. Keszei, G. Y. Cserep

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Theophylline concentrations in saliva and serum were compared in 20 patients with essential tremor. There was a strong correlation between the concentrations in saliva and serum (r = 0.9, slope of 0.48). The ratio between unbound and bound theophylline as assessed by ultrafiltration was 0.30. This ratio was similar to that between theophylline concentrations in CSF and serum. The theophylline concentration in serum was not predictable from that obtained in saliva in individual cases. Moreover, the levels in saliva were about 20% higher than the unbound concentrations of theophylline in serum.

Original languageEnglish
Pages (from-to)135-137
Number of pages3
JournalTherapeutic Drug Monitoring
Volume14
Issue number2
Publication statusPublished - 1992

Fingerprint

Cerebrospinal fluid
Essential Tremor
Theophylline
Saliva
Cerebrospinal Fluid
Serum
Ultrafiltration

Keywords

  • Essential tremor
  • Theophylline

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Toxicology

Cite this

Theophylline concentrations in serum, saliva, and cerebrospinal fluid in patients with essential tremor. / Málly, J.; Keszei, C. S.; Cserep, G. Y.

In: Therapeutic Drug Monitoring, Vol. 14, No. 2, 1992, p. 135-137.

Research output: Contribution to journalArticle

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