Themechanism of reduced longitudinal left ventricular systolic function in hypertensive patients with normal ejection fraction

Zsuzsanna Szelényi, Ádám Fazakas, G. Szénási, Narcis Tegze, Bertalan Fekete, A. Molvarec, Soma Hadusfalvy-Sudár, Olivér Jánosi, Melinda Kiss, I. Karádi, András Vereckei

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: MacIver and Townsend's hypothesis predicts, based on a mathematical model of left ventricular contraction, that preserved absolute radial wall thickening (radWT) due to left ventricular hypertrophy is responsible for the normal ejection fraction in patients with heart failure with preserved ejection fraction (HFPEF). Methods: We tested the validity of this hypothesis by detailed echocardiography including evaluation of ventricular myocardial strain (S) using speckle tracking imaging in at least 60-year-old 18 controls and 94 hypertensive patients with normal ejection fraction. Results: Echocardiography revealed no left ventricular diastolic dysfunction in 38 out of 94 (40%) patients with hypertension (HTDD-negative group), and 56 out of 94 (60%) patients had diastolic dysfunction (HTDD-positive groups). The absolute values of global longitudinal left ventricular peak systolic S were significantly reduced in both patient groups (P

Original languageEnglish
Pages (from-to)1962-1969
Number of pages8
JournalJournal of Hypertension
Volume33
Issue number9
DOIs
Publication statusPublished - 2015

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Left Ventricular Function
Echocardiography
Left Ventricular Dysfunction
Left Ventricular Hypertrophy
Theoretical Models
Heart Failure
Hypertension

Keywords

  • Heart failure with preserved ejection fraction
  • Hypertension
  • Left ventricular function

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Themechanism of reduced longitudinal left ventricular systolic function in hypertensive patients with normal ejection fraction. / Szelényi, Zsuzsanna; Fazakas, Ádám; Szénási, G.; Tegze, Narcis; Fekete, Bertalan; Molvarec, A.; Hadusfalvy-Sudár, Soma; Jánosi, Olivér; Kiss, Melinda; Karádi, I.; Vereckei, András.

In: Journal of Hypertension, Vol. 33, No. 9, 2015, p. 1962-1969.

Research output: Contribution to journalArticle

Szelényi, Zsuzsanna ; Fazakas, Ádám ; Szénási, G. ; Tegze, Narcis ; Fekete, Bertalan ; Molvarec, A. ; Hadusfalvy-Sudár, Soma ; Jánosi, Olivér ; Kiss, Melinda ; Karádi, I. ; Vereckei, András. / Themechanism of reduced longitudinal left ventricular systolic function in hypertensive patients with normal ejection fraction. In: Journal of Hypertension. 2015 ; Vol. 33, No. 9. pp. 1962-1969.
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