A Whitehall tanulmány és diabetológiai vonatkozásai

Translated title of the contribution: The Whitehall studies and their relevance to diabetes research and clinical practice

A. Tabák, Eric J. Brunner, Daniel R. Witte, Kivimäki Mika

Research output: Contribution to journalArticle

Abstract

Aim: The Whitehall studies aimed to investigate the social and biological risk factors of physical and mental illness. Methods: The Whitehall studies are occupational cohorts, targeting civil servants working in the London offices. Whitehall is a classical epidemiological cohort with a baseline examination (including a 50g challenge test) in 1967-1970, and an ongoing mortality follow-up. The baseline for Whitehall II is 1985-88. Participants had repeated screenings 5 yearly thereafter (including a 75g OGTT). Results: The Whitehall studies found that diabetes is associated with an increased mortality. Furthermore they observed that elevated postchallenge glucose even within the normal range is associated with an increased mortality. Factor analysis described a healthy diet that is related to decreased incidence of diabetes. They also proved the "grade gradient" in the development of diabetes and metabolic syndrome. CRP was found not to be causally involved in the development of diabetes. Elevated interleukin-1 receptor antagonist is an independent predictor of type 2 diabetes. By the investigation of growths curves they were able to describe the pathophysiological changes preceding incident diabetes. Conclusions: The Whitehall studies with their wide scope of risk factors significantly advanced our knowledge on the public health importance of diabetes and on its pathophysiology.

Original languageHungarian
Pages (from-to)163-173
Number of pages11
JournalOrvoskepzes
Volume85
Issue number2
Publication statusPublished - 2010

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Mortality
Research
Interleukin-1 Receptors
Biological Factors
Glucose Tolerance Test
Type 2 Diabetes Mellitus
Statistical Factor Analysis
Reference Values
Cohort Studies
Public Health
Glucose
Incidence
Growth
Healthy Diet

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tabák, A., Brunner, E. J., Witte, D. R., & Mika, K. (2010). A Whitehall tanulmány és diabetológiai vonatkozásai. Orvoskepzes, 85(2), 163-173.

A Whitehall tanulmány és diabetológiai vonatkozásai. / Tabák, A.; Brunner, Eric J.; Witte, Daniel R.; Mika, Kivimäki.

In: Orvoskepzes, Vol. 85, No. 2, 2010, p. 163-173.

Research output: Contribution to journalArticle

Tabák, A, Brunner, EJ, Witte, DR & Mika, K 2010, 'A Whitehall tanulmány és diabetológiai vonatkozásai', Orvoskepzes, vol. 85, no. 2, pp. 163-173.
Tabák A, Brunner EJ, Witte DR, Mika K. A Whitehall tanulmány és diabetológiai vonatkozásai. Orvoskepzes. 2010;85(2):163-173.
Tabák, A. ; Brunner, Eric J. ; Witte, Daniel R. ; Mika, Kivimäki. / A Whitehall tanulmány és diabetológiai vonatkozásai. In: Orvoskepzes. 2010 ; Vol. 85, No. 2. pp. 163-173.
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