The versatile functions of complement C3-derived ligands

Anna Erdei, Noémi Sándor, Bernadett Mácsik-Valent, Szilvia Lukácsi, Mariann Kremlitzka, Zsuzsa Bajtay

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

The complement system is a major component of immune defense. Activation of the complement cascade by foreign substances and altered self-structures may lead to the elimination of the activating agent, and during the enzymatic cascade, several biologically active fragments are generated. Most immune regulatory effects of complement are mediated by the activation products of C3, the central component. The indispensable role of C3 in opsonic phagocytosis as well as in the regulation of humoral immune response is known for long, while the involvement of complement in T-cell biology have been revealed in the past few years. In this review, we discuss the immune modulatory functions of C3-derived fragments focusing on their role in processes which have not been summarized so far. The importance of locally synthesized complement will receive special emphasis, as several immunological processes take place in tissues, where hepatocyte-derived complement components might not be available at high concentrations. We also aim to call the attention to important differences between human and mouse systems regarding C3-mediated processes.

Original languageEnglish
Pages (from-to)127-140
Number of pages14
JournalImmunological Reviews
Volume274
Issue number1
DOIs
Publication statusPublished - Nov 1 2016

Keywords

  • B cell
  • cell activation
  • complement
  • dendritic cell
  • monocyte/macrophage

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Erdei, A., Sándor, N., Mácsik-Valent, B., Lukácsi, S., Kremlitzka, M., & Bajtay, Z. (2016). The versatile functions of complement C3-derived ligands. Immunological Reviews, 274(1), 127-140. https://doi.org/10.1111/imr.12498