The velocities of red cell and plasma flows through parenchymal microvessels of rat brain are decreased by pentobarbital

Ling Wei, Tadahiro Otsuka, Virgil Acuff, D. Bereczki, Karen Pettigrew, Clifford Patlak, Joseph Fenstermacher

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Local cerebral blood flow is lowered in many brain areas of the rat by high-dose pentobarbital (50 mg/ kg). In the present study, the mechanism of this flow change was examined by measuring the distribution of radiolabeled red blood cells (RBCs) and albumin (RISA) in small parenchymal microvessels and calculating the microvascular distribution spaces and mean transit times of RBCs, RISA, and blood. In most brain areas, pentobarbital slightly decreased the RISA space, modestly increased the RBC space, and did not alter the blood space. The mean transit times of RBCs, RISA, and blood through the perfused microvessels were considerably greater in treated rats than in controls. These findings indicate that the mechanism by which high-dose pentobarbital diminishes local cerebral blood flow in rat brain is, in the main, a lowered linear velocity of plasma and RBC flow through small parenchymal microvessels and not decreased percentage of perfused capillaries (capillary retirement). This response is probably driven mainly by lowered local metabolism and may well entail a slight increase in the number of small microvessels that are perfused by RBCs.

Original languageEnglish
Pages (from-to)487-497
Number of pages11
JournalJournal of Cerebral Blood Flow and Metabolism
Volume13
Issue number3
Publication statusPublished - 1993

Fingerprint

Pentobarbital
Microvessels
Plasma Cells
Erythrocytes
Cerebrovascular Circulation
Brain
Retirement
Albumins

Keywords

  • Capillary recruitment
  • Capillary retirement
  • Hematic capillaries
  • Hypercapnia
  • Plasmatic capillaries
  • Transit times

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Neuroscience(all)

Cite this

The velocities of red cell and plasma flows through parenchymal microvessels of rat brain are decreased by pentobarbital. / Wei, Ling; Otsuka, Tadahiro; Acuff, Virgil; Bereczki, D.; Pettigrew, Karen; Patlak, Clifford; Fenstermacher, Joseph.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 13, No. 3, 1993, p. 487-497.

Research output: Contribution to journalArticle

Wei, Ling ; Otsuka, Tadahiro ; Acuff, Virgil ; Bereczki, D. ; Pettigrew, Karen ; Patlak, Clifford ; Fenstermacher, Joseph. / The velocities of red cell and plasma flows through parenchymal microvessels of rat brain are decreased by pentobarbital. In: Journal of Cerebral Blood Flow and Metabolism. 1993 ; Vol. 13, No. 3. pp. 487-497.
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