The value of ECG and echocardiography during stress testing for identifying systemic endothelial dysfunction and epicardial artery stenosis

A. Pálinkás, E. Tóth, R. Amyot, F. Rigo, L. Venneria, Eugenio Picano

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Background: In the stress imaging era, ECG positivity is regarded as a frequent source of false-positive responses. However, it is known that normal coronary arteries frequently coexist with abnormal endothelial function in patients with chest pain. Aim: To evaluate the anatomical coronary epicardial, and functional systemic endothelial determinants of wall motion and electrocardiographic responses during stress testing. Method: Sixty-eight in-hospital patients with chest pain syndrome, no previous myocardial infarction, and off nitrate therapy at the time of testing underwent, on different days, in random order and within 1 month: (1) stress ECG echo testing (with dipyridamole in 43, dobutamine in 3, and exercise in 22 patients); (2) coronary angiography; (3) endothelium-dependent, flow-mediated dilation of the brachial artery during reactive hyperaemia using high-resolution ultrasound. Criteria of positivity were: ST segment depression >0.1 mm in the stress ECG; regional dysfunction >2 segments demonstrated by stress-echo; diameter reduction >50% on coronary angiography; and

Original languageEnglish
Pages (from-to)1587-1595
Number of pages9
JournalEuropean Heart Journal
Volume23
Issue number20
DOIs
Publication statusPublished - Oct 2002

Fingerprint

Stress Echocardiography
Electrocardiography
Pathologic Constriction
Arteries
Coronary Angiography
Chest Pain
Dobutamine
Brachial Artery
Dipyridamole
Hyperemia
Nitrates
Endothelium
Dilatation
Coronary Vessels
Myocardial Infarction
Exercise
Therapeutics

Keywords

  • Electrocardiography
  • Endothelium
  • Stress echocardiography
  • Ultrasound

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The value of ECG and echocardiography during stress testing for identifying systemic endothelial dysfunction and epicardial artery stenosis. / Pálinkás, A.; Tóth, E.; Amyot, R.; Rigo, F.; Venneria, L.; Picano, Eugenio.

In: European Heart Journal, Vol. 23, No. 20, 10.2002, p. 1587-1595.

Research output: Contribution to journalArticle

Pálinkás, A. ; Tóth, E. ; Amyot, R. ; Rigo, F. ; Venneria, L. ; Picano, Eugenio. / The value of ECG and echocardiography during stress testing for identifying systemic endothelial dysfunction and epicardial artery stenosis. In: European Heart Journal. 2002 ; Vol. 23, No. 20. pp. 1587-1595.
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