The use of fish in carcinogenesis studies

K. Lapis, K. Simon, B. Szende

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The study of a possible carcinogenic effect of substances introduced in increasing number by technological development is an essential, but extremely expensive, work and time consuming procedure. In vitro short term test is not a substitute for in vivo animal experiments, which are carried out traditionally on rodents. Carcinogenesis studies on fish are promising models since shorter time is needed for them, and they are less expensive than those on rodents. Parallel observations on these two species favourably complement each other by helping to meet, with lower expenses, the internationally accepted requirements that the carcinogenicity testing of substances should be carried out on at least two species. The authors stand for the application of fishes under adequate circumstances in carcinogenesis screening. The results of investigations from the literature are presented with the species of fish used, applied doses of carcinogens, the most frequent tumors brought about by them, and the subsequent tasks related to carcinogenesis studies on fish.

Original languageEnglish
Pages (from-to)75-86
Number of pages12
JournalMagyar Onkologia
Volume22
Issue number2
Publication statusPublished - 1978

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Carcinogenesis
Fishes
Rodentia
Carcinogens
Neoplasms

ASJC Scopus subject areas

  • Cancer Research

Cite this

The use of fish in carcinogenesis studies. / Lapis, K.; Simon, K.; Szende, B.

In: Magyar Onkologia, Vol. 22, No. 2, 1978, p. 75-86.

Research output: Contribution to journalArticle

Lapis, K. ; Simon, K. ; Szende, B. / The use of fish in carcinogenesis studies. In: Magyar Onkologia. 1978 ; Vol. 22, No. 2. pp. 75-86.
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