Az ursodezoxikólsav-p-aminobenzoesav teszt a kontaminált vékonybélszindróma diagnosztikájában.

Translated title of the contribution: The ursodeoxycholic acid-p-aminobenzoic acid test in the diagnosis of small bowel bacterial overgrowth syndrome

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Contaminated small bowel syndrome is frequently associated with meteorism due to excessive gas formation, and diarrhoea as a result of bacterial fermentative processes, including splitting of carbohydrates or deconjugating and dehydroxylating bile salts. In addition to gas production, bacteria capable of metabolizing bile salts have been shown to release p-aminobenzoic acid (PABA) from and Ursodeoxycholic-acid-PABA substrate. Our aim was to determine the possible complementary role of the UDCA-PABA test in the diagnosis of bacterial overgrowth. PATIENTS AND METHODS: The H2 breath and UDCA-PABA tests were performed simultaneously on 46 patients with suspected contaminated small bowel syndrome, and on 7 healthy subjects. The H2 breath test was performed by oral loading of 25 g lactose and/or 10 g lactulose. The UDCA-PABA test was carried out by determining urinary excretion of PABA after oral loading with 250 mg UDCA-PABA conjugate. The diagnosis of bacterial overgrowth was established, when either H2 breath, or UDCA-PABA test proved to be pathological. RESULTS: Based upon the pathologic values of either the H2 breath test, or the UDCA-PABA test, 25 out of 46 patients proved to have contaminated small bowel syndrome. In 10 out of 25 patients only pathologic urinary PABA excretion (12.772 +/- 1.707 vs 4.1 +/- 0.58), indicated bacterial overgrowth, and in 9 out of the same group only positive H2 breath test (early rise of > 20 ppm of H2) indicated the same, while in 6 cases both tests proved to be pathological. In 7 CSBS patients the urinary excretion of PABA significantly decreased following a 10 day Tinidazole treatment (5.48 +/- 1.286 vs 13.068 +/- 2.068). CONCLUSION: The UDCA-PABA test proved to be a valuable complementary method to detect bacterial overgrowth, when H2 production failed to reveal bacterial overgrowth.

Original languageHungarian
Pages (from-to)1255-1258
Number of pages4
JournalOrvosi Hetilap
Volume138
Issue number20
Publication statusPublished - May 18 1997

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Blind Loop Syndrome
4-Aminobenzoic Acid
Ursodeoxycholic Acid
Breath Tests
Bile Acids and Salts
Bacterial Physiological Phenomena
Gases
Tinidazole
Lactulose
Lactose

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az ursodezoxikólsav-p-aminobenzoesav teszt a kontaminált vékonybélszindróma diagnosztikájában. / Kiss, Z.; Wölfling, J.; Csáti, S.; Nagy, F.; Lonovics, J.; Schneider, G.

In: Orvosi Hetilap, Vol. 138, No. 20, 18.05.1997, p. 1255-1258.

Research output: Contribution to journalArticle

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title = "Az ursodezoxik{\'o}lsav-p-aminobenzoesav teszt a kontamin{\'a}lt v{\'e}konyb{\'e}lszindr{\'o}ma diagnosztik{\'a}j{\'a}ban.",
abstract = "Contaminated small bowel syndrome is frequently associated with meteorism due to excessive gas formation, and diarrhoea as a result of bacterial fermentative processes, including splitting of carbohydrates or deconjugating and dehydroxylating bile salts. In addition to gas production, bacteria capable of metabolizing bile salts have been shown to release p-aminobenzoic acid (PABA) from and Ursodeoxycholic-acid-PABA substrate. Our aim was to determine the possible complementary role of the UDCA-PABA test in the diagnosis of bacterial overgrowth. PATIENTS AND METHODS: The H2 breath and UDCA-PABA tests were performed simultaneously on 46 patients with suspected contaminated small bowel syndrome, and on 7 healthy subjects. The H2 breath test was performed by oral loading of 25 g lactose and/or 10 g lactulose. The UDCA-PABA test was carried out by determining urinary excretion of PABA after oral loading with 250 mg UDCA-PABA conjugate. The diagnosis of bacterial overgrowth was established, when either H2 breath, or UDCA-PABA test proved to be pathological. RESULTS: Based upon the pathologic values of either the H2 breath test, or the UDCA-PABA test, 25 out of 46 patients proved to have contaminated small bowel syndrome. In 10 out of 25 patients only pathologic urinary PABA excretion (12.772 +/- 1.707 vs 4.1 +/- 0.58), indicated bacterial overgrowth, and in 9 out of the same group only positive H2 breath test (early rise of > 20 ppm of H2) indicated the same, while in 6 cases both tests proved to be pathological. In 7 CSBS patients the urinary excretion of PABA significantly decreased following a 10 day Tinidazole treatment (5.48 +/- 1.286 vs 13.068 +/- 2.068). CONCLUSION: The UDCA-PABA test proved to be a valuable complementary method to detect bacterial overgrowth, when H2 production failed to reveal bacterial overgrowth.",
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T1 - Az ursodezoxikólsav-p-aminobenzoesav teszt a kontaminált vékonybélszindróma diagnosztikájában.

AU - Kiss, Z.

AU - Wölfling, J.

AU - Csáti, S.

AU - Nagy, F.

AU - Lonovics, J.

AU - Schneider, G.

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