The unequal expression of human α-globin genes at the protein level

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Abstract

Chromatographic and electrophoretic quantitation of the two different kinds of abnormal α-chain variants, present in the double heterozygote for Hb J Buda/Hb A/Hb G Pest, revealed a relative abundance of Hb J Buda in the young red cells in comparison to the old and total erythrocyte populations of the same individual. This result is in good agreement with the literature on the unequal mRNA production of the two α-globin genes, providing the supposition that unequal α-gene expression is manifested at the protein level in humans too.

Original languageEnglish
JournalBiomedica Biochimica Acta
Volume42
Issue number11-12
Publication statusPublished - 1983

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Globins
Genes
Heterozygote
Gene expression
Proteins
Erythrocytes
Cells
Gene Expression
Messenger RNA
Population
hemoglobin J-Buda
hemoglobin G Pest

ASJC Scopus subject areas

  • Biochemistry

Cite this

The unequal expression of human α-globin genes at the protein level. / Szelényi, J.; Horányi, M.; Foldi, J.; Hollán, S.

In: Biomedica Biochimica Acta, Vol. 42, No. 11-12, 1983.

Research output: Contribution to journalArticle

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