The TRPA1 Activator Allyl Isothiocyanate (AITC) Contracts Human Jejunal Muscle

Pharmacological Analysis

Zsolt Sandor, Andras Dekany, Dezsö Kelemen, Timea Bencsik, Robert Papp, L. Barthó

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The contractile effect of AITC (300 μM) on human jejunal longitudinal strips was inhibited by the TRPA1 antagonist HC 030031 and atropine or scopolamine, but was insensitive to tetrodotoxin, purinoceptor antagonists or capsaicin desensitization. It is concluded that TRPA1 activation stimulates a cholinergic mechanism in a tetrodotoxin-resistant manner.

Original languageEnglish
Pages (from-to)341-342
Number of pages2
JournalBasic and Clinical Pharmacology and Toxicology
Volume119
Issue number3
DOIs
Publication statusPublished - Sep 1 2016

Fingerprint

Tetrodotoxin
Contracts
Muscle
Purinergic Antagonists
Pharmacology
Muscles
Scopolamine Hydrobromide
Capsaicin
Atropine
Cholinergic Agents
Chemical activation
allyl isothiocyanate
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide

ASJC Scopus subject areas

  • Medicine(all)
  • Toxicology
  • Pharmacology

Cite this

The TRPA1 Activator Allyl Isothiocyanate (AITC) Contracts Human Jejunal Muscle : Pharmacological Analysis. / Sandor, Zsolt; Dekany, Andras; Kelemen, Dezsö; Bencsik, Timea; Papp, Robert; Barthó, L.

In: Basic and Clinical Pharmacology and Toxicology, Vol. 119, No. 3, 01.09.2016, p. 341-342.

Research output: Contribution to journalArticle

Sandor, Zsolt ; Dekany, Andras ; Kelemen, Dezsö ; Bencsik, Timea ; Papp, Robert ; Barthó, L. / The TRPA1 Activator Allyl Isothiocyanate (AITC) Contracts Human Jejunal Muscle : Pharmacological Analysis. In: Basic and Clinical Pharmacology and Toxicology. 2016 ; Vol. 119, No. 3. pp. 341-342.
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