The triple classification of dry eye for practical clinical use

Juan Murube, J. Németh, H. Höh, P. Kaynak-Hekimhan, J. Horwath-Winter, A. Agarwal, C. Baudouin, J. M. Benítez Del Castillo, S. Cervenka, L. Chenzhuo, A. Ducasse, J. Durán, F. Holly, R. Javate, J. Nepp, F. Paulsen, A. Rahimi, P. Raus, O. Shalaby, P. Sieg & 4 others H. Soriano, D. Spinelli, S. H. Ugurbas, G. Van Setten

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

PURPOSE. "Dry Eye is a condition produced by the inadequate interrelation between lacrimal film and ocular surface epithelium, and is caused by quantitative and qualitative deficits in one or both of them. It can be produced by one or combined etiologic causes, affecting one or several of the secretions of the glands serving the ocular surface, and producing secondary manifestations of different grades of severity". Clinicians need a practical classification to face diagnosis, prognosis and treatment. Dry eyes have many etiologies and pathogenesis, different affectation of the various dacryoglands and ocular surface epithelium, and diverse grades of severity. The specialists in xero-dacryology must know these three parameters to evaluate any case of dry eye, and to establish an adequate treatment. METHODS. To facilitate this, an open session in the 8th congress of the International Society of Dacryology and Dry Eye (Madrid, April, 2005) proposed modifying the Triple Classification of dry eye approved in the XIV congress of the European Society of Ophthalmology (Madrid, June, 2003). There was consensus of all conclusions. CONCLUSIONS. The following classification has been established: First, a classification of the etio-pathogenesis, distributed in ten groups: age-related, hormonal, pharmacologic, immunopathic, hyponutritional, dysgenic, infectious/inflammatory, traumatic, neurologic and tantalic. Second, a classification of the affected glands and tissues, which under the acronym of ALMEN includes the Aqueo-serousdeficient, Lipodeficient, Mucindeficient and Epitheliopatic dry eyes, and the Non dacryological affected exocrine glands (saliva, nasal secretion, tracheo-pharyngeal secretion, etc). And thirdly, a classification of severity, in three grades: Grade 1 or mild (symptoms without slitlamp signs), grade 2 or moderate (symptoms with reversible signs), and grade 3 or severe (symptoms with permanent signs).

Original languageEnglish
Pages (from-to)660-667
Number of pages8
JournalEuropean Journal of Ophthalmology
Volume15
Issue number6
Publication statusPublished - Nov 2005

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Epithelium
Exocrine Glands
Tears
Nose
Saliva
Nervous System
Age Groups
Therapeutics

Keywords

  • Dry eye
  • Tears
  • Triple Classification

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Murube, J., Németh, J., Höh, H., Kaynak-Hekimhan, P., Horwath-Winter, J., Agarwal, A., ... Van Setten, G. (2005). The triple classification of dry eye for practical clinical use. European Journal of Ophthalmology, 15(6), 660-667.

The triple classification of dry eye for practical clinical use. / Murube, Juan; Németh, J.; Höh, H.; Kaynak-Hekimhan, P.; Horwath-Winter, J.; Agarwal, A.; Baudouin, C.; Benítez Del Castillo, J. M.; Cervenka, S.; Chenzhuo, L.; Ducasse, A.; Durán, J.; Holly, F.; Javate, R.; Nepp, J.; Paulsen, F.; Rahimi, A.; Raus, P.; Shalaby, O.; Sieg, P.; Soriano, H.; Spinelli, D.; Ugurbas, S. H.; Van Setten, G.

In: European Journal of Ophthalmology, Vol. 15, No. 6, 11.2005, p. 660-667.

Research output: Contribution to journalArticle

Murube, J, Németh, J, Höh, H, Kaynak-Hekimhan, P, Horwath-Winter, J, Agarwal, A, Baudouin, C, Benítez Del Castillo, JM, Cervenka, S, Chenzhuo, L, Ducasse, A, Durán, J, Holly, F, Javate, R, Nepp, J, Paulsen, F, Rahimi, A, Raus, P, Shalaby, O, Sieg, P, Soriano, H, Spinelli, D, Ugurbas, SH & Van Setten, G 2005, 'The triple classification of dry eye for practical clinical use', European Journal of Ophthalmology, vol. 15, no. 6, pp. 660-667.
Murube J, Németh J, Höh H, Kaynak-Hekimhan P, Horwath-Winter J, Agarwal A et al. The triple classification of dry eye for practical clinical use. European Journal of Ophthalmology. 2005 Nov;15(6):660-667.
Murube, Juan ; Németh, J. ; Höh, H. ; Kaynak-Hekimhan, P. ; Horwath-Winter, J. ; Agarwal, A. ; Baudouin, C. ; Benítez Del Castillo, J. M. ; Cervenka, S. ; Chenzhuo, L. ; Ducasse, A. ; Durán, J. ; Holly, F. ; Javate, R. ; Nepp, J. ; Paulsen, F. ; Rahimi, A. ; Raus, P. ; Shalaby, O. ; Sieg, P. ; Soriano, H. ; Spinelli, D. ; Ugurbas, S. H. ; Van Setten, G. / The triple classification of dry eye for practical clinical use. In: European Journal of Ophthalmology. 2005 ; Vol. 15, No. 6. pp. 660-667.
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AU - Murube, Juan

AU - Németh, J.

AU - Höh, H.

AU - Kaynak-Hekimhan, P.

AU - Horwath-Winter, J.

AU - Agarwal, A.

AU - Baudouin, C.

AU - Benítez Del Castillo, J. M.

AU - Cervenka, S.

AU - Chenzhuo, L.

AU - Ducasse, A.

AU - Durán, J.

AU - Holly, F.

AU - Javate, R.

AU - Nepp, J.

AU - Paulsen, F.

AU - Rahimi, A.

AU - Raus, P.

AU - Shalaby, O.

AU - Sieg, P.

AU - Soriano, H.

AU - Spinelli, D.

AU - Ugurbas, S. H.

AU - Van Setten, G.

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N2 - PURPOSE. "Dry Eye is a condition produced by the inadequate interrelation between lacrimal film and ocular surface epithelium, and is caused by quantitative and qualitative deficits in one or both of them. It can be produced by one or combined etiologic causes, affecting one or several of the secretions of the glands serving the ocular surface, and producing secondary manifestations of different grades of severity". Clinicians need a practical classification to face diagnosis, prognosis and treatment. Dry eyes have many etiologies and pathogenesis, different affectation of the various dacryoglands and ocular surface epithelium, and diverse grades of severity. The specialists in xero-dacryology must know these three parameters to evaluate any case of dry eye, and to establish an adequate treatment. METHODS. To facilitate this, an open session in the 8th congress of the International Society of Dacryology and Dry Eye (Madrid, April, 2005) proposed modifying the Triple Classification of dry eye approved in the XIV congress of the European Society of Ophthalmology (Madrid, June, 2003). There was consensus of all conclusions. CONCLUSIONS. The following classification has been established: First, a classification of the etio-pathogenesis, distributed in ten groups: age-related, hormonal, pharmacologic, immunopathic, hyponutritional, dysgenic, infectious/inflammatory, traumatic, neurologic and tantalic. Second, a classification of the affected glands and tissues, which under the acronym of ALMEN includes the Aqueo-serousdeficient, Lipodeficient, Mucindeficient and Epitheliopatic dry eyes, and the Non dacryological affected exocrine glands (saliva, nasal secretion, tracheo-pharyngeal secretion, etc). And thirdly, a classification of severity, in three grades: Grade 1 or mild (symptoms without slitlamp signs), grade 2 or moderate (symptoms with reversible signs), and grade 3 or severe (symptoms with permanent signs).

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