The tripeptide aldehyde, Boc-DPhe-Phe-Lysinal, is a novel Ca2+ channel inhibitor in pituitary cells

Gábor B. Makara, György Rappay, Vera Garamvölgyi, Iván Nagy, Stefánia Dankó, Sándor Bajusz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effect of Boc-DPhe-Phe-Lysinal (Boc-DPPL) on the 45Ca2+ uptake of rat anterior pituitary monolayer cultures was investigated. The compound decreased the basal Ca2+ uptake at 3 × 10-4 mol/l. The 45Ca2+ uptake stimulated by potassium-induced depolarization was more sensitive to Boc-DPPL inhibition, a slight decrease was seen with 3 × 10-6 mol/l and there was a half maximal inhibition at 3 × 10-5 mol/l. Boc-DPPL is known to inhibit pituitary hormone release in similar concentrations, an effect might also be due to its calcium antagonist property.

Original languageEnglish
Pages (from-to)147-149
Number of pages3
JournalEuropean Journal of Pharmacology
Volume151
Issue number1
DOIs
Publication statusPublished - Jun 22 1988

Keywords

  • Calcium uptake
  • K depolarization
  • Proteinase inhibitor
  • Voltage-dependent Ca channels

ASJC Scopus subject areas

  • Pharmacology

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