The tripeptide aldehyde, Boc-DPhe-Phe-Lysinal, is a novel Ca2+ channel inhibitor in pituitary cells

G. Makara, György Rappay, Vera Garamvölgyi, Iván Nagy, Stefánia Dankó, Sándor Bajusz

Research output: Contribution to journalArticle

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Abstract

The effect of Boc-DPhe-Phe-Lysinal (Boc-DPPL) on the 45Ca2+ uptake of rat anterior pituitary monolayer cultures was investigated. The compound decreased the basal Ca2+ uptake at 3 × 10-4 mol/l. The 45Ca2+ uptake stimulated by potassium-induced depolarization was more sensitive to Boc-DPPL inhibition, a slight decrease was seen with 3 × 10-6 mol/l and there was a half maximal inhibition at 3 × 10-5 mol/l. Boc-DPPL is known to inhibit pituitary hormone release in similar concentrations, an effect might also be due to its calcium antagonist property.

Original languageEnglish
Pages (from-to)147-149
Number of pages3
JournalEuropean Journal of Pharmacology
Volume151
Issue number1
DOIs
Publication statusPublished - Jun 22 1988

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Pituitary Hormones
Aldehydes
Potassium
Calcium

Keywords

  • Calcium uptake
  • K depolarization
  • Proteinase inhibitor
  • Voltage-dependent Ca channels

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

The tripeptide aldehyde, Boc-DPhe-Phe-Lysinal, is a novel Ca2+ channel inhibitor in pituitary cells. / Makara, G.; Rappay, György; Garamvölgyi, Vera; Nagy, Iván; Dankó, Stefánia; Bajusz, Sándor.

In: European Journal of Pharmacology, Vol. 151, No. 1, 22.06.1988, p. 147-149.

Research output: Contribution to journalArticle

Makara, G. ; Rappay, György ; Garamvölgyi, Vera ; Nagy, Iván ; Dankó, Stefánia ; Bajusz, Sándor. / The tripeptide aldehyde, Boc-DPhe-Phe-Lysinal, is a novel Ca2+ channel inhibitor in pituitary cells. In: European Journal of Pharmacology. 1988 ; Vol. 151, No. 1. pp. 147-149.
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