The TRIGR trial: Testing the potential link between weaning diet and type 1 diabetes

Hans K. Åkerblom, Mikael Knip, Dorothy Becker, Hans Michael Dosch, John Dupré, Jorma Ilonen, Jeffrey P. Kriseher, M. Maria Craig, Patricia Crock, Neville Howard, Lise Belanger, Tracey Bridger, George Carson, Cheril Clarson, Elizabeth Cummings, Denis Daneman, Hans Michael Dosch, John Dupré, William Fraser, Rose GirgisJahanara Hasan, Celine Huot, Margaret Lawson, Laurent Legault, Daniel Metzger, James Popkin, Susan Sanderson, Koravangattu Sankaran, David Stephure, Shayne Taback, Alan White, Ludmila Brazdova, Hana Krauseova, Jaroslav Skvor, Zdenka Tomsikova, Jan Vavrinec, Jitrenka Venhacova, Anne Ormisson, Mall Anne Riikjärv, Hans K. Åkerblom, Hannu Haavisto, Anu Maaria Hämäläinen, Vilho Hiilesmaa, Carita Holm, Heikki Hyöty, Jorma Ilonen, Anna Liisa Järvenpää, Mikael Knip, Jorma Komulainen, Paavo Korpela, Pentti Lautala, Kaija Lindström, Raisa Lounamaa, Päivi Nykänen, Kari Ranta, Martin Renlund, Antti Reunanen, Erkki Savilahti, Ilkka Sipilä, Leena Taittonen, Timo Talvitie, Päivi Tapanainen, Kari Teramo, Outi Vaarala, Ritva Virransalo, Suvi Virtanen, Thomas Danne, Olga Kordonouri, L. Madácsy, Paolo Pozzilli, Marco Songini, Crine De Beaufort, Jan Bruining, Jerzy Bodalski, Hanna Dziatkowiak, Przemyslawa Jarosz-Chobot, Renata Wasikowa, Jan Wilczyński, Luis Castano, Luis Ortiz Quintana, Luis Felipe Pallardo, Manuel Serrano-Rios, Jan Åman, Hans Edenwall, Hans Fors, Ragnar Hanas, Calle Johansson, Bengt Lindblad, Agne Lindh, Johnny Ludvigsson, Nils Östen Nilsson, Maria Nordwall, Eugen Schoenle, Dorothy Becker, Uday Devaskar, Teresa Frazer, Robin Goland, Jeffrey P. Krischer, Jerry P. Palmer

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In the following we briefly update the information on the study which testa our hypothesized role of the weaning diet in the etiology of type 1 diabetes (T1D), and describe the ongoing Trial to Reduce IDDM in the Genetically at Risk (TRIGR). The study will determine whether weaning to a formula in which cow milk (CM) proteins (the most common intact foreign weaning protein in humans) have been extensively hydrolyzed, reduces risk for T1D in genetically susceptible children. This double blind, randomized controlled trial in subjects with affected first-degree relatives and risk-associated HLA genotypes, requires 2032 eligible infants: 4516 newbom babies need to be recruited, 45% of which are predicted to have eligible HLA geaotypes. An international, multicenter consortium has been established comprising 78 centers in 15 countries. By the end of November 2005 we had achieved 81% of the recruitment target with 4396 infanta registered, 3896 randomized and 1644 eligible infanta entered into the intervention. The 6-8 month intervention is designed to compare the effects of either hydrolyzed casein or standard CM based weaning formula. Duration of breasffeeding is at the mothers' discretion. All subjects are observed for 10 years with measurements of serological markers of intact CM exposure, diabetes predictive antoantibodies (endpoint at age 6 years) and progression to clinical T1D (endpoint at age 10 years). If the intervention is effective in delaying autoimmunity or its progression to diabetes, this first ever primary prevention study of T1D, will have far-reaching impact for families with members at risk.

Original languageEnglish
Pages (from-to)251-263
Number of pages13
JournalImmunology, Endocrine and Metabolic Agents in Medicinal Chemistry
Volume7
Issue number3
DOIs
Publication statusPublished - Jun 2007

Fingerprint

Weaning
Type 1 Diabetes Mellitus
Diet
Milk
Milk Proteins
Primary Prevention
Caseins
Autoimmunity
Randomized Controlled Trials
Genotype
Mothers
Proteins

Keywords

  • Cow milk
  • DQB1
  • HLA Genotyping
  • Non-obese diabetic mice
  • TRIGR pilot study

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Pharmacology

Cite this

The TRIGR trial : Testing the potential link between weaning diet and type 1 diabetes. / Åkerblom, Hans K.; Knip, Mikael; Becker, Dorothy; Dosch, Hans Michael; Dupré, John; Ilonen, Jorma; Kriseher, Jeffrey P.; Craig, M. Maria; Crock, Patricia; Howard, Neville; Belanger, Lise; Bridger, Tracey; Carson, George; Clarson, Cheril; Cummings, Elizabeth; Daneman, Denis; Dosch, Hans Michael; Dupré, John; Fraser, William; Girgis, Rose; Hasan, Jahanara; Huot, Celine; Lawson, Margaret; Legault, Laurent; Metzger, Daniel; Popkin, James; Sanderson, Susan; Sankaran, Koravangattu; Stephure, David; Taback, Shayne; White, Alan; Brazdova, Ludmila; Krauseova, Hana; Skvor, Jaroslav; Tomsikova, Zdenka; Vavrinec, Jan; Venhacova, Jitrenka; Ormisson, Anne; Riikjärv, Mall Anne; Åkerblom, Hans K.; Haavisto, Hannu; Hämäläinen, Anu Maaria; Hiilesmaa, Vilho; Holm, Carita; Hyöty, Heikki; Ilonen, Jorma; Järvenpää, Anna Liisa; Knip, Mikael; Komulainen, Jorma; Korpela, Paavo; Lautala, Pentti; Lindström, Kaija; Lounamaa, Raisa; Nykänen, Päivi; Ranta, Kari; Renlund, Martin; Reunanen, Antti; Savilahti, Erkki; Sipilä, Ilkka; Taittonen, Leena; Talvitie, Timo; Tapanainen, Päivi; Teramo, Kari; Vaarala, Outi; Virransalo, Ritva; Virtanen, Suvi; Danne, Thomas; Kordonouri, Olga; Madácsy, L.; Pozzilli, Paolo; Songini, Marco; De Beaufort, Crine; Bruining, Jan; Bodalski, Jerzy; Dziatkowiak, Hanna; Jarosz-Chobot, Przemyslawa; Wasikowa, Renata; Wilczyński, Jan; Castano, Luis; Ortiz Quintana, Luis; Pallardo, Luis Felipe; Serrano-Rios, Manuel; Åman, Jan; Edenwall, Hans; Fors, Hans; Hanas, Ragnar; Johansson, Calle; Lindblad, Bengt; Lindh, Agne; Ludvigsson, Johnny; Nilsson, Nils Östen; Nordwall, Maria; Schoenle, Eugen; Becker, Dorothy; Devaskar, Uday; Frazer, Teresa; Goland, Robin; Krischer, Jeffrey P.; Palmer, Jerry P.

In: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, Vol. 7, No. 3, 06.2007, p. 251-263.

Research output: Contribution to journalArticle

Åkerblom, HK, Knip, M, Becker, D, Dosch, HM, Dupré, J, Ilonen, J, Kriseher, JP, Craig, MM, Crock, P, Howard, N, Belanger, L, Bridger, T, Carson, G, Clarson, C, Cummings, E, Daneman, D, Dosch, HM, Dupré, J, Fraser, W, Girgis, R, Hasan, J, Huot, C, Lawson, M, Legault, L, Metzger, D, Popkin, J, Sanderson, S, Sankaran, K, Stephure, D, Taback, S, White, A, Brazdova, L, Krauseova, H, Skvor, J, Tomsikova, Z, Vavrinec, J, Venhacova, J, Ormisson, A, Riikjärv, MA, Åkerblom, HK, Haavisto, H, Hämäläinen, AM, Hiilesmaa, V, Holm, C, Hyöty, H, Ilonen, J, Järvenpää, AL, Knip, M, Komulainen, J, Korpela, P, Lautala, P, Lindström, K, Lounamaa, R, Nykänen, P, Ranta, K, Renlund, M, Reunanen, A, Savilahti, E, Sipilä, I, Taittonen, L, Talvitie, T, Tapanainen, P, Teramo, K, Vaarala, O, Virransalo, R, Virtanen, S, Danne, T, Kordonouri, O, Madácsy, L, Pozzilli, P, Songini, M, De Beaufort, C, Bruining, J, Bodalski, J, Dziatkowiak, H, Jarosz-Chobot, P, Wasikowa, R, Wilczyński, J, Castano, L, Ortiz Quintana, L, Pallardo, LF, Serrano-Rios, M, Åman, J, Edenwall, H, Fors, H, Hanas, R, Johansson, C, Lindblad, B, Lindh, A, Ludvigsson, J, Nilsson, NÖ, Nordwall, M, Schoenle, E, Becker, D, Devaskar, U, Frazer, T, Goland, R, Krischer, JP & Palmer, JP 2007, 'The TRIGR trial: Testing the potential link between weaning diet and type 1 diabetes', Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, vol. 7, no. 3, pp. 251-263. https://doi.org/10.2174/187152207780832315
Åkerblom, Hans K. ; Knip, Mikael ; Becker, Dorothy ; Dosch, Hans Michael ; Dupré, John ; Ilonen, Jorma ; Kriseher, Jeffrey P. ; Craig, M. Maria ; Crock, Patricia ; Howard, Neville ; Belanger, Lise ; Bridger, Tracey ; Carson, George ; Clarson, Cheril ; Cummings, Elizabeth ; Daneman, Denis ; Dosch, Hans Michael ; Dupré, John ; Fraser, William ; Girgis, Rose ; Hasan, Jahanara ; Huot, Celine ; Lawson, Margaret ; Legault, Laurent ; Metzger, Daniel ; Popkin, James ; Sanderson, Susan ; Sankaran, Koravangattu ; Stephure, David ; Taback, Shayne ; White, Alan ; Brazdova, Ludmila ; Krauseova, Hana ; Skvor, Jaroslav ; Tomsikova, Zdenka ; Vavrinec, Jan ; Venhacova, Jitrenka ; Ormisson, Anne ; Riikjärv, Mall Anne ; Åkerblom, Hans K. ; Haavisto, Hannu ; Hämäläinen, Anu Maaria ; Hiilesmaa, Vilho ; Holm, Carita ; Hyöty, Heikki ; Ilonen, Jorma ; Järvenpää, Anna Liisa ; Knip, Mikael ; Komulainen, Jorma ; Korpela, Paavo ; Lautala, Pentti ; Lindström, Kaija ; Lounamaa, Raisa ; Nykänen, Päivi ; Ranta, Kari ; Renlund, Martin ; Reunanen, Antti ; Savilahti, Erkki ; Sipilä, Ilkka ; Taittonen, Leena ; Talvitie, Timo ; Tapanainen, Päivi ; Teramo, Kari ; Vaarala, Outi ; Virransalo, Ritva ; Virtanen, Suvi ; Danne, Thomas ; Kordonouri, Olga ; Madácsy, L. ; Pozzilli, Paolo ; Songini, Marco ; De Beaufort, Crine ; Bruining, Jan ; Bodalski, Jerzy ; Dziatkowiak, Hanna ; Jarosz-Chobot, Przemyslawa ; Wasikowa, Renata ; Wilczyński, Jan ; Castano, Luis ; Ortiz Quintana, Luis ; Pallardo, Luis Felipe ; Serrano-Rios, Manuel ; Åman, Jan ; Edenwall, Hans ; Fors, Hans ; Hanas, Ragnar ; Johansson, Calle ; Lindblad, Bengt ; Lindh, Agne ; Ludvigsson, Johnny ; Nilsson, Nils Östen ; Nordwall, Maria ; Schoenle, Eugen ; Becker, Dorothy ; Devaskar, Uday ; Frazer, Teresa ; Goland, Robin ; Krischer, Jeffrey P. ; Palmer, Jerry P. / The TRIGR trial : Testing the potential link between weaning diet and type 1 diabetes. In: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 2007 ; Vol. 7, No. 3. pp. 251-263.
@article{c31929e51fe6467a8ade2aa571969e71,
title = "The TRIGR trial: Testing the potential link between weaning diet and type 1 diabetes",
abstract = "In the following we briefly update the information on the study which testa our hypothesized role of the weaning diet in the etiology of type 1 diabetes (T1D), and describe the ongoing Trial to Reduce IDDM in the Genetically at Risk (TRIGR). The study will determine whether weaning to a formula in which cow milk (CM) proteins (the most common intact foreign weaning protein in humans) have been extensively hydrolyzed, reduces risk for T1D in genetically susceptible children. This double blind, randomized controlled trial in subjects with affected first-degree relatives and risk-associated HLA genotypes, requires 2032 eligible infants: 4516 newbom babies need to be recruited, 45{\%} of which are predicted to have eligible HLA geaotypes. An international, multicenter consortium has been established comprising 78 centers in 15 countries. By the end of November 2005 we had achieved 81{\%} of the recruitment target with 4396 infanta registered, 3896 randomized and 1644 eligible infanta entered into the intervention. The 6-8 month intervention is designed to compare the effects of either hydrolyzed casein or standard CM based weaning formula. Duration of breasffeeding is at the mothers' discretion. All subjects are observed for 10 years with measurements of serological markers of intact CM exposure, diabetes predictive antoantibodies (endpoint at age 6 years) and progression to clinical T1D (endpoint at age 10 years). If the intervention is effective in delaying autoimmunity or its progression to diabetes, this first ever primary prevention study of T1D, will have far-reaching impact for families with members at risk.",
keywords = "Cow milk, DQB1, HLA Genotyping, Non-obese diabetic mice, TRIGR pilot study",
author = "{\AA}kerblom, {Hans K.} and Mikael Knip and Dorothy Becker and Dosch, {Hans Michael} and John Dupr{\'e} and Jorma Ilonen and Kriseher, {Jeffrey P.} and Craig, {M. Maria} and Patricia Crock and Neville Howard and Lise Belanger and Tracey Bridger and George Carson and Cheril Clarson and Elizabeth Cummings and Denis Daneman and Dosch, {Hans Michael} and John Dupr{\'e} and William Fraser and Rose Girgis and Jahanara Hasan and Celine Huot and Margaret Lawson and Laurent Legault and Daniel Metzger and James Popkin and Susan Sanderson and Koravangattu Sankaran and David Stephure and Shayne Taback and Alan White and Ludmila Brazdova and Hana Krauseova and Jaroslav Skvor and Zdenka Tomsikova and Jan Vavrinec and Jitrenka Venhacova and Anne Ormisson and Riikj{\"a}rv, {Mall Anne} and {\AA}kerblom, {Hans K.} and Hannu Haavisto and H{\"a}m{\"a}l{\"a}inen, {Anu Maaria} and Vilho Hiilesmaa and Carita Holm and Heikki Hy{\"o}ty and Jorma Ilonen and J{\"a}rvenp{\"a}{\"a}, {Anna Liisa} and Mikael Knip and Jorma Komulainen and Paavo Korpela and Pentti Lautala and Kaija Lindstr{\"o}m and Raisa Lounamaa and P{\"a}ivi Nyk{\"a}nen and Kari Ranta and Martin Renlund and Antti Reunanen and Erkki Savilahti and Ilkka Sipil{\"a} and Leena Taittonen and Timo Talvitie and P{\"a}ivi Tapanainen and Kari Teramo and Outi Vaarala and Ritva Virransalo and Suvi Virtanen and Thomas Danne and Olga Kordonouri and L. Mad{\'a}csy and Paolo Pozzilli and Marco Songini and {De Beaufort}, Crine and Jan Bruining and Jerzy Bodalski and Hanna Dziatkowiak and Przemyslawa Jarosz-Chobot and Renata Wasikowa and Jan Wilczyński and Luis Castano and {Ortiz Quintana}, Luis and Pallardo, {Luis Felipe} and Manuel Serrano-Rios and Jan {\AA}man and Hans Edenwall and Hans Fors and Ragnar Hanas and Calle Johansson and Bengt Lindblad and Agne Lindh and Johnny Ludvigsson and Nilsson, {Nils {\"O}sten} and Maria Nordwall and Eugen Schoenle and Dorothy Becker and Uday Devaskar and Teresa Frazer and Robin Goland and Krischer, {Jeffrey P.} and Palmer, {Jerry P.}",
year = "2007",
month = "6",
doi = "10.2174/187152207780832315",
language = "English",
volume = "7",
pages = "251--263",
journal = "Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry",
issn = "1871-5222",
publisher = "Bentham Science Publishers B.V.",
number = "3",

}

TY - JOUR

T1 - The TRIGR trial

T2 - Testing the potential link between weaning diet and type 1 diabetes

AU - Åkerblom, Hans K.

AU - Knip, Mikael

AU - Becker, Dorothy

AU - Dosch, Hans Michael

AU - Dupré, John

AU - Ilonen, Jorma

AU - Kriseher, Jeffrey P.

AU - Craig, M. Maria

AU - Crock, Patricia

AU - Howard, Neville

AU - Belanger, Lise

AU - Bridger, Tracey

AU - Carson, George

AU - Clarson, Cheril

AU - Cummings, Elizabeth

AU - Daneman, Denis

AU - Dosch, Hans Michael

AU - Dupré, John

AU - Fraser, William

AU - Girgis, Rose

AU - Hasan, Jahanara

AU - Huot, Celine

AU - Lawson, Margaret

AU - Legault, Laurent

AU - Metzger, Daniel

AU - Popkin, James

AU - Sanderson, Susan

AU - Sankaran, Koravangattu

AU - Stephure, David

AU - Taback, Shayne

AU - White, Alan

AU - Brazdova, Ludmila

AU - Krauseova, Hana

AU - Skvor, Jaroslav

AU - Tomsikova, Zdenka

AU - Vavrinec, Jan

AU - Venhacova, Jitrenka

AU - Ormisson, Anne

AU - Riikjärv, Mall Anne

AU - Åkerblom, Hans K.

AU - Haavisto, Hannu

AU - Hämäläinen, Anu Maaria

AU - Hiilesmaa, Vilho

AU - Holm, Carita

AU - Hyöty, Heikki

AU - Ilonen, Jorma

AU - Järvenpää, Anna Liisa

AU - Knip, Mikael

AU - Komulainen, Jorma

AU - Korpela, Paavo

AU - Lautala, Pentti

AU - Lindström, Kaija

AU - Lounamaa, Raisa

AU - Nykänen, Päivi

AU - Ranta, Kari

AU - Renlund, Martin

AU - Reunanen, Antti

AU - Savilahti, Erkki

AU - Sipilä, Ilkka

AU - Taittonen, Leena

AU - Talvitie, Timo

AU - Tapanainen, Päivi

AU - Teramo, Kari

AU - Vaarala, Outi

AU - Virransalo, Ritva

AU - Virtanen, Suvi

AU - Danne, Thomas

AU - Kordonouri, Olga

AU - Madácsy, L.

AU - Pozzilli, Paolo

AU - Songini, Marco

AU - De Beaufort, Crine

AU - Bruining, Jan

AU - Bodalski, Jerzy

AU - Dziatkowiak, Hanna

AU - Jarosz-Chobot, Przemyslawa

AU - Wasikowa, Renata

AU - Wilczyński, Jan

AU - Castano, Luis

AU - Ortiz Quintana, Luis

AU - Pallardo, Luis Felipe

AU - Serrano-Rios, Manuel

AU - Åman, Jan

AU - Edenwall, Hans

AU - Fors, Hans

AU - Hanas, Ragnar

AU - Johansson, Calle

AU - Lindblad, Bengt

AU - Lindh, Agne

AU - Ludvigsson, Johnny

AU - Nilsson, Nils Östen

AU - Nordwall, Maria

AU - Schoenle, Eugen

AU - Becker, Dorothy

AU - Devaskar, Uday

AU - Frazer, Teresa

AU - Goland, Robin

AU - Krischer, Jeffrey P.

AU - Palmer, Jerry P.

PY - 2007/6

Y1 - 2007/6

N2 - In the following we briefly update the information on the study which testa our hypothesized role of the weaning diet in the etiology of type 1 diabetes (T1D), and describe the ongoing Trial to Reduce IDDM in the Genetically at Risk (TRIGR). The study will determine whether weaning to a formula in which cow milk (CM) proteins (the most common intact foreign weaning protein in humans) have been extensively hydrolyzed, reduces risk for T1D in genetically susceptible children. This double blind, randomized controlled trial in subjects with affected first-degree relatives and risk-associated HLA genotypes, requires 2032 eligible infants: 4516 newbom babies need to be recruited, 45% of which are predicted to have eligible HLA geaotypes. An international, multicenter consortium has been established comprising 78 centers in 15 countries. By the end of November 2005 we had achieved 81% of the recruitment target with 4396 infanta registered, 3896 randomized and 1644 eligible infanta entered into the intervention. The 6-8 month intervention is designed to compare the effects of either hydrolyzed casein or standard CM based weaning formula. Duration of breasffeeding is at the mothers' discretion. All subjects are observed for 10 years with measurements of serological markers of intact CM exposure, diabetes predictive antoantibodies (endpoint at age 6 years) and progression to clinical T1D (endpoint at age 10 years). If the intervention is effective in delaying autoimmunity or its progression to diabetes, this first ever primary prevention study of T1D, will have far-reaching impact for families with members at risk.

AB - In the following we briefly update the information on the study which testa our hypothesized role of the weaning diet in the etiology of type 1 diabetes (T1D), and describe the ongoing Trial to Reduce IDDM in the Genetically at Risk (TRIGR). The study will determine whether weaning to a formula in which cow milk (CM) proteins (the most common intact foreign weaning protein in humans) have been extensively hydrolyzed, reduces risk for T1D in genetically susceptible children. This double blind, randomized controlled trial in subjects with affected first-degree relatives and risk-associated HLA genotypes, requires 2032 eligible infants: 4516 newbom babies need to be recruited, 45% of which are predicted to have eligible HLA geaotypes. An international, multicenter consortium has been established comprising 78 centers in 15 countries. By the end of November 2005 we had achieved 81% of the recruitment target with 4396 infanta registered, 3896 randomized and 1644 eligible infanta entered into the intervention. The 6-8 month intervention is designed to compare the effects of either hydrolyzed casein or standard CM based weaning formula. Duration of breasffeeding is at the mothers' discretion. All subjects are observed for 10 years with measurements of serological markers of intact CM exposure, diabetes predictive antoantibodies (endpoint at age 6 years) and progression to clinical T1D (endpoint at age 10 years). If the intervention is effective in delaying autoimmunity or its progression to diabetes, this first ever primary prevention study of T1D, will have far-reaching impact for families with members at risk.

KW - Cow milk

KW - DQB1

KW - HLA Genotyping

KW - Non-obese diabetic mice

KW - TRIGR pilot study

UR - http://www.scopus.com/inward/record.url?scp=34347348955&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34347348955&partnerID=8YFLogxK

U2 - 10.2174/187152207780832315

DO - 10.2174/187152207780832315

M3 - Article

AN - SCOPUS:34347348955

VL - 7

SP - 251

EP - 263

JO - Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry

JF - Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry

SN - 1871-5222

IS - 3

ER -