From practical point of view it is useful to divide urinary tract infections (UTI) into those that are uncomplicated (normal urinary tract and normal renal function) and those that are complicated (abnormal urinary tract, impaired host defences, renal insufficiency, infection with a virulent organism, all UTI in males). In the presence of uncomplicated and complicated UTIs, the main therapeutic objectives should be to eradicate the microorganisms invading the urine, renal parenchima and the blood. The choice of antibiotics is a difficult task. On the basis of current literature data pharmacokinetic view points are reviewed. Pharmacokinetic and pharmacodynamic studies suggest that quinolones which penetrate well the infected renal parenchyma and are not impaired by the local inflammatory process, should, with the exception of pyelonephritis in pregnancy and childhood, be preferred to be as first-choice agents for the therapy of UTI-s.
|Translated title of the contribution||The treatment of urinary tract infections - Pharmacokinetic view points|
|Number of pages||9|
|Publication status||Published - Jan 1 1999|
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