The pathogenesis of acne, the most frequent skin disorder, has not been elucidated in detail. Recent scientific findings indicate that the decisive pathobiochemical defect underlying acne is a disturbance of lipid metabolism in the follicular epithelium as a result of linoleic acid deficiency. Phosphatidylcholine, isolated from soybean lecithine, contains 70 % linoleic acid, which is bound on Uie glycerol backbone. Two products, Phospholipon 80 and 90, containing 80 and 92 % phosphatidylcholine respectively have been used as a source of bound linoleic acid in drugs for over 25 years.These two products were tested in different carrier systems in 7 controlled studies, in the treatment of patients (n = 77) with acne vulgaris.As efficacy variables (he number of comedones and efflorescences were rated. The results of the studies were compiled and are summarized by the following graplis: Reduction of number of comedones [%] Redaction of number of efflorescences [%] The concomitant increase of Imoleic acid and decrease of squaleiie in the skin surface lipids was observed in 11 itcourse of tlie treatment. In these studies no side effects were observed and the compliance was excellent. The anti-acne efficacy is comparable if the products are formulated in water, water-alcohol systems. Phosphatidylcboline-bound Linoleic Acid may constitute thus: - a new therapeutic principle, - advantages for patients and - a new advance in the direction of a causal therapy for the treatment of acne and disturbances of the lipiU metabolism in the skin.
|Number of pages||2|
|Publication status||Published - Dec 1 1996|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology (medical)