The transgenic rabbit as model for human diseases and as a source of biologically active recombinant proteins

Z. Bösze, L. Hiripi, J. W. Carnwath, H. Niemann

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Until recently, transgenic rabbits were produced exclusively by pronuclear microinjection which results in additive random insertional transgenesis; however, progress in somatic cell cloning based on nuclear transfer will soon make it possible to produce rabbits with modifications to specific genes by the combination of homologous recombination and subsequent prescreening of nuclear donor cells. Transgenic rabbits have been found to be excellent animal models for inherited and acquired human diseases including hypertrophic cardiomyopathy, perturbed lipoprotein metabolism and atherosclerosis. Transgenic rabbits have also proved to be suitable bioreactors for the production of recombinant protein both on an experimental and a commercial scale. This review summarizes recent research based on the transgenic rabbit model.

Original languageEnglish
Pages (from-to)541-553
Number of pages13
JournalTransgenic Research
Volume12
Issue number5
DOIs
Publication statusPublished - Oct 2003

Fingerprint

Recombinant Proteins
human diseases
recombinant proteins
rabbits
genetically modified organisms
Rabbits
cloning (cells)
Gene Transfer Techniques
Homologous Recombination
homologous recombination
Hypertrophic Cardiomyopathy
cardiomyopathy
Microinjections
Bioreactors
bioreactors
atherosclerosis
somatic cells
lipoproteins
Lipoproteins
Organism Cloning

Keywords

  • Antiviral
  • Bioreactor
  • Cardiomyopathy
  • Lipid metabolism
  • Pharmaceutical
  • Rabbit

ASJC Scopus subject areas

  • Genetics
  • Plant Science
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Biotechnology
  • Food Science

Cite this

The transgenic rabbit as model for human diseases and as a source of biologically active recombinant proteins. / Bösze, Z.; Hiripi, L.; Carnwath, J. W.; Niemann, H.

In: Transgenic Research, Vol. 12, No. 5, 10.2003, p. 541-553.

Research output: Contribution to journalArticle

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