The thermal and photostability of solid pharmaceuticals

A review

B. D. Glass, C. Novák, M. E. Brown

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Drugs degrade to different extents on separate exposure to heat, moisture, oxidation and light. Combination of these stresses causes very complex behaviour. Many studies have been reported of the thermal behaviour of drugs in the solid-state, but most of the information available on the photodegradation of drugs refers to reactions in solution, (usually aqueous) and photoreactions in the solid-state are even more complex. In drug formulations, the presence of excipients adds further complications because the excipients may increase, have no effect on, or decrease the inherent stabilities of the drug. The literature has been explored to review the thermal and photostabilities of solid pharmaccuticals.

Original languageEnglish
Pages (from-to)1013-1036
Number of pages24
JournalJournal of Thermal Analysis and Calorimetry
Volume77
Issue number3
DOIs
Publication statusPublished - 2004

Fingerprint

Drug products
drugs
Excipients
Pharmaceutical Preparations
Photodegradation
solid state
Moisture
Oxidation
moisture
Hot Temperature
aqueous solutions
formulations
heat
oxidation
causes
Pharmaceutical Chemistry

Keywords

  • Drugs
  • Kinetic analysis
  • Pharmaceuticals
  • Photostability
  • Thermal analysis
  • Thermal stability

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

The thermal and photostability of solid pharmaceuticals : A review. / Glass, B. D.; Novák, C.; Brown, M. E.

In: Journal of Thermal Analysis and Calorimetry, Vol. 77, No. 3, 2004, p. 1013-1036.

Research output: Contribution to journalArticle

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