The tetranucleotide hypothesis: A centennial

Research output: Contribution to journalEditorial

9 Citations (Scopus)


Phoebus Aaron Levene established the tetranucleotide hypothesis for the structure of nucleic acids in 1909 and kept refining it during the ensuing three decades of his life. To some, this hypothesis was a major obstacle in recognizing the ability of desoxyribonucleic acid of being the substance of heredity. To others, Levene's discovery was a milestone in the quest for uncovering the chemistry of life.

Original languageEnglish
Pages (from-to)753-756
Number of pages4
JournalStructural Chemistry
Issue number5
Publication statusPublished - Jul 29 2009


  • Phoebus Levene
  • Structure of nucleic acids
  • Tetranucleotide hypothesis

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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