The synthesis of risedronic acid and alendronate applying phosphorus oxychloride and phosphorous acid in methanesulfonic acid

Alajos Grün, Rita Kovács, Sándor Garadnay, István Greiner, György Keglevich

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The synthesis of risedronic acid and alendronate from 3-pyridylacetic acid and γ-aminobutyric acid, respectively, using phosphorus oxychloride and phosphorous acid as the P-reagents and methanesulfonic acid as the solvent was optimized, and the role of phosphorus oxychloride and phosphorous acid in the reaction was clarified.

Original languageEnglish
Pages (from-to)253-258
Number of pages6
JournalLetters in Drug Design and Discovery
Volume12
Issue number4
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Alendronate
  • Mechanism
  • Optimization
  • Phosphorous acid
  • Phosphorus oxychloride
  • Risedronic acid
  • Synthesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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