The synthesis of N,N-Bis(dialkoxyphosphinoylmethyl)- and N,N-Bis(diphenylphosphinoylmethyl)glycine esters by the microwave-assisted double kabachnik-fields reaction

Erika Bálint, Eszter Fazekas, László Drahos, György Keglevich

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The condensation of a glycine ester, two equivalents of paraformaldehyde, and the same quantity of a dialkyl phosphite or diphenylphosphine oxide afforded the title compounds as new bis(phospha-Mannich) products under microwave (MW) conditions at 100°C. The dialkoxyphosphinoylmethyl derivatives were synthesized under solvent-free conditions, whereas the diphenylphosphinoylmethyl derivatives were synthesized in acetonitrile solution. Comparative thermal experiments showed the beneficial role of MW in respect of efficiency.

Original languageEnglish
Pages (from-to)510-515
Number of pages6
JournalHeteroatom Chemistry
Volume24
Issue number6
DOIs
Publication statusPublished - Nov 1 2013

ASJC Scopus subject areas

  • Chemistry(all)

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