The synthesis of D-heteroannulated 3β-hydroxy-13α-androst-5-ene derivatives via α-oxoketene dithioacetal and α-oxohydroxymethylidene synthons

Ágota Szájli, János Wölfling

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

16-Ketene dithioacetal derivatives of 3β-hydroxy-13α-androst-5- en-17-one react with amidine, benzamidine, or guanidine to yield novel pyrimido-fused D-heteroannulated steroids. The reactions of 3β-hydroxy-16- hydroxymethylidene-13α-androst-5-en-17-one with N,N′-dinucleophiles furnish heterocycles containing a pyrazole ring fused to positions 16,17 of the sterane skeleton.

Original languageEnglish
Pages (from-to)1431-1440
Number of pages10
JournalMonatshefte fur Chemie
Volume137
Issue number11
DOIs
Publication statusPublished - Nov 1 2006

Keywords

  • Heterocycles
  • Lewis acids
  • Pyrazolones
  • Pyrimidines
  • Steroids

ASJC Scopus subject areas

  • Chemistry(all)

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