The SYK tyrosine kinase: A crucial player in diverse biological functions

A. Mócsai, Jürgen Ruland, Victor L J Tybulewicz

Research output: Contribution to journalArticle

615 Citations (Scopus)

Abstract

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates new targets, including the CARD9-BCL-10-MALT1 pathway and the NLRP3 inflammasome. Studies using Drosophila melanogaster suggest that there is an evolutionarily ancient origin of SYK-mediated signalling. Moreover, SYK has a crucial role in autoimmune diseases and haematological malignancies. This Review summarizes our current understanding of the diverse functions of SYK and how this is being translated for therapeutic purposes.

Original languageEnglish
Pages (from-to)387-402
Number of pages16
JournalNature Reviews Immunology
Volume10
Issue number6
DOIs
Publication statusPublished - May 2010

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Protein-Tyrosine Kinases
Inflammasomes
C-Type Lectins
Platelet Activation
Osteoclasts
Hematologic Neoplasms
Drosophila melanogaster
Integrins
Autoimmune Diseases
Blood Vessels
Syk Kinase

ASJC Scopus subject areas

  • Immunology

Cite this

The SYK tyrosine kinase : A crucial player in diverse biological functions. / Mócsai, A.; Ruland, Jürgen; Tybulewicz, Victor L J.

In: Nature Reviews Immunology, Vol. 10, No. 6, 05.2010, p. 387-402.

Research output: Contribution to journalArticle

Mócsai, A. ; Ruland, Jürgen ; Tybulewicz, Victor L J. / The SYK tyrosine kinase : A crucial player in diverse biological functions. In: Nature Reviews Immunology. 2010 ; Vol. 10, No. 6. pp. 387-402.
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