The surprising dual action of glucocorticoids

Ludmila Filaretova, Gábor Makara

Research output: Contribution to journalArticle

2 Citations (Scopus)


Glucocorticoid hormones may have dual action on the stomach: physiological gastroprotective and pathological proulcerogenic one. In physiological conditions, even in acute stress situations, glucocorticoids have an adaptive effect on the stomach and, therefore, are gastroprotective. The findings that we review in this article suggest that glucocorticoids released during acute stress are naturally occurring protective factors that play an important role in maintenance of the gastric mucosal integrity.

Original languageEnglish
Pages (from-to)121-123
Number of pages3
JournalIdeggyogyaszati szemle
Issue number3-4
Publication statusPublished - Mar 3 2014



  • Gastric erosion
  • Gastroprotection
  • Glucocorticoids
  • Hans Selye
  • Non-steroidal anti-inflammatory drugs
  • Stress
  • The hypothalamic-pituitary-adrenocortical axis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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