The superoxide scavenging activity of dihydroquinoline type derivatives (CH402 and MTDQ-DA)

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Abstract

Electron paramagnetic resonance/spin trapping studies were applied, to verify the superoxide radical scavenging activity of two non-toxic, water soluble dihydroquinoline type antioxidants, CH402 (Na-2, 2-dimethyl-1,2-dihydroquinoline-4-yl methane sulphonate and MTDQ-DA (6,6-methylene bis 2,2-dimethyl-4-methane sulphonic acid: Na-1,2-dihydroquinoline). Results were compared with other indirect methods such as the amperometric, spectrophotometric and luminometric methods, respectively. Both dihydroquinoline type antioxidants scavenged superoxide in vitro specifically. MTDQ-DA scavenged superoxide an order of magnitude faster than CH-402. Neither CH402 nor MTDQ-DA affected the hypoxanthine/xanthine oxidase superoxide generating system, nor did they inhibit xanthine oxidase directly.

Original languageEnglish
Pages (from-to)287-296
Number of pages10
JournalFree radical research
Volume19
Issue number5
DOIs
Publication statusPublished - Jan 1 1993

Keywords

  • CH402
  • Dihydroquinoline type antioxidant
  • Electron paramagnetic resonance/spin trapping
  • MTDQ-DA
  • Superoxide scavenger

ASJC Scopus subject areas

  • Biochemistry

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