The spontaneous rosette forming activity of 40 ALL and 32 control infants were studied. The peripheral lymphocytes of the control children bind in a median rate of 27.5% sheep red blood cells to their surface. The rosette forming activity of lymphoblasts of leukemic children is significantly decreased (median 4.6%). The number of rosette forming cells during intensive induction chemotherapy was much less than that of the controls (15.7%), while the lymphocytes of children in remission, obtaining maintenance therapy formed rosettes nearly in the normal rate (median 22.5%). The presence of sera obtained from leukemia patients before chemotherapy had no considerable effect on the rosette forming capacity of lymphocytes either of the controls or of the leukemic patients.
|Number of pages||4|
|Publication status||Published - Jan 1 1975|
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