The structure of N,N′-di-l-phenylalanine hydrazide determined by X-ray diffraction methods

X. Urbańczyk-Lipkowski, J. W. Krajewski, P. Gluziński, A. W. Lipkowski, Gy Argay

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8 Citations (Scopus)


The molecular structure of N,N′-di-l-phenylalanine hydrazide, regarded as a model molecule for hydrazine-bridged enkephalins, has been determined by X-ray diffraction methods. The compound crystallizes in the orthorhombic systems, space group P212121 with cell dimensions a = 8.523(1), b = 10.804(1), and c = 19.536(4) Å. The structure was solved by direct methods are refined in anisotropic mode giving R = 0.046 for 1929 observed reflections. The central hydrazide part of the molecule is almost planar and the probable existence of two fused five-membered chelate rings with NH··OC intramolecular hydrogen bonds is observed. The amino hydrogen atoms are found free of interactions. In the terms of this observations the biological activity of hydrazine-bridged enkephalins may be elucidated.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalJournal of Molecular Structure
Issue number1-2
Publication statusPublished - Jan 1986

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Inorganic Chemistry

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