The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules

Research output: Contribution to journalReview article

139 Citations (Scopus)

Abstract

We here attempt to achieve an integrated understanding of the structure and dynamics of a number of higher-order assemblies, including amyloids, various kinds of signalosomes, and cellular granules. We propose that the synergy between folded domains, linear motifs, and intrinsically disordered regions regulates the formation and intrinsic fuzziness of all higher-order assemblies, creating a structural and dynamic continuum. We describe how such regulatory mechanisms could be influenced under pathological conditions.

Original languageEnglish
Pages (from-to)1055-1066
Number of pages12
JournalCell
Volume165
Issue number5
DOIs
Publication statusPublished - May 19 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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