The strategy of picornavirus evading host antiviral responses: Nonstructural proteins suppress the production of IFNs

Yining Wang, Lina Ma, Laszlo Stipkovits, Susan Szathmary, Xuerui Li, Yongsheng Liu

Research output: Contribution to journalReview article

Abstract

Viral infections trigger the innate immune system to produce interferons (IFNs), which play important role in host antiviral responses. Co-evolution of viruses with their hosts has favored development of various strategies to evade the effects of IFNs, enabling viruses to survive inside host cells. One such strategy involves inhibition of IFN signaling pathways by non-structural proteins. In this review, we provide a brief overview of host signaling pathways inducing IFN production and their suppression by picornavirus non-structural proteins. Using this strategy, picornaviruses can evade the host immune response and replicate inside host cells.

Original languageEnglish
Article number2943
JournalFrontiers in Microbiology
Volume9
Issue numberDEC
DOIs
Publication statusPublished - Dec 11 2018

Keywords

  • IFNs
  • Immune evasion
  • Non-structural proteins
  • Picornaviruses
  • Signaling pathways

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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