The species-specific acid-base and multinuclear magnetic resonance properties of selenocysteamine, selenocysteine, and their homodiselenides

Tamás Pálla, Arash Mirzahosseini, Béla Noszál

Research output: Contribution to journalArticle

Abstract

Selenol-compounds were studied by 1H, 13C, and 77Se NMR spectroscopy as a function of pH, and their acid-base properties were analysed by case-tailored evaluation methods. Macroscopic and microscopic protonation constants were determined, and the concomitant interactivity parameters were calculated. The species- and site-specific protonation constants are interpreted by means of inductive and shielding effects, also, in comparison with their sulfur containing analogues. The species-specific chemical shifts of these compounds show close correlation with the corresponding selenolate protonation constants. This relationship is observed and described for selenolates for the first time, and allows the prediction of selenolate oxidizabilities in important biomolecules.

Original languageEnglish
Article number137076
JournalChemical Physics Letters
Volume741
DOIs
Publication statusPublished - Feb 16 2020

Fingerprint

Selenocysteine
Protonation
Magnetic resonance
magnetic resonance
acids
Acids
Chemical shift
Biomolecules
Sulfur
Shielding
Nuclear magnetic resonance spectroscopy
shielding
chemical equilibrium
sulfur
analogs
nuclear magnetic resonance
evaluation
predictions
spectroscopy

Keywords

  • Se NMR
  • Diselenide
  • Microspeciation
  • NMR-pH titration
  • PK
  • Selenol

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

Cite this

The species-specific acid-base and multinuclear magnetic resonance properties of selenocysteamine, selenocysteine, and their homodiselenides. / Pálla, Tamás; Mirzahosseini, Arash; Noszál, Béla.

In: Chemical Physics Letters, Vol. 741, 137076, 16.02.2020.

Research output: Contribution to journalArticle

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