The somatostatin analog, octreotide, causes accumulation of growth hormone-releasing hormone and depletion of angiotensin in the rat hypothalamus

J. Gardi, E. Szentirmai, I. Hajdu, F. Obal, J. M. Krueger

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Rats were injected intracerebroventricularly with the somatostatin analog, octreotide (OCT; 0.1 μg) or vehicle, and hypothalamic contents of growth hormone-releasing hormone (GHRH), angiotensin II, and vasopressin were determined 10 min, 1, 3 and 6 h post-injection. OCT elicited an immediate release of angiotensin II (10 min) and a rise in GHRH content (1 h) followed by gradual (1-6 h) depletion of accumulated GHRH. Hypothalamic vasopressin was not altered but decreases in pituitary vasopressin occurred 10 min post-injection. The OCT-induced alterations in GHRH may explain previously reported changes in sleep whereas angiotensin may mediate OCT-induced drinking, vasopressin secretion and rises in blood pressure via sst2 somatostatin receptors.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalNeuroscience Letters
Volume315
Issue number1-2
DOIs
Publication statusPublished - Nov 23 2001

Fingerprint

Growth Hormone-Releasing Hormone
Octreotide
Angiotensins
Somatostatin
Vasopressins
Hypothalamus
Angiotensin II
Somatostatin Receptors
Injections
Drinking
Sleep
Blood Pressure

Keywords

  • Angiotensin
  • Drinking
  • Growth hormone-releasing hormone
  • Sleep
  • Somatostatin
  • Thirst
  • Vasopressin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The somatostatin analog, octreotide, causes accumulation of growth hormone-releasing hormone and depletion of angiotensin in the rat hypothalamus. / Gardi, J.; Szentirmai, E.; Hajdu, I.; Obal, F.; Krueger, J. M.

In: Neuroscience Letters, Vol. 315, No. 1-2, 23.11.2001, p. 37-40.

Research output: Contribution to journalArticle

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