The small molecular mass antifungal protein of Penicillium chrysogenum - A mechanism of action oriented review

Nikoletta Hegedus, Éva Leiter, Barbara Kovács, Valéria Tomori, Nak Jung Kwon, Tamás Emri, Florentine Marx, Gyula Batta, László Csernoch, Hubertus Haas, Jae Hyuk Yu, István Pócsi

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

The β-lactam producing filamentous fungus Penicillium chrysogenum secretes a 6.25 kDa small molecular mass antifungal protein, PAF, which has a highly stable, compact 3D structure and is effective against a wide spectrum of plant and zoo pathogenic fungi. Its precise physiological functions and mode of action need to be elucidated before considering possible biomedical, agricultural or food technological applications. According to some more recent experimental data, PAF plays an important role in the fine-tuning of conidiogenesis in Penicillium chrysogenum. PAF triggers apoptotic cell death in sensitive fungi, and cell death signaling may be transmitted through two-component systems, heterotrimeric G protein coupled signal transduction and regulatory networks as well as via alteration of the Ca 2+-homeostasis of the cells. Possible biotechnological applications of PAF are also outlined in the review.

Original languageEnglish
Pages (from-to)561-571
Number of pages11
JournalJournal of basic microbiology
Volume51
Issue number6
DOIs
Publication statusPublished - Dec 1 2011

Keywords

  • Apoptosis
  • Conidiation
  • G protein signaling
  • Oxidative stress
  • Two-component signaling

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology

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