The site-dependent growth characteristics of a human xenotransplanted basaloid squamous cell carcinoma

I. Babó, J. Bocsi, A. Jeney

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: To improve our understanding of the aggressive behaviour of basaloid squamous cell carcinoma (BSCC) certain biological features related to malignancy were compared in the basaloid and in the squamous cell population of this tumour. Methods: Growth rate, cell population kinetics parameters, ploidy and collagenase activity were measured in BSCC xenotransplanted subcutaneously or into oral submucosa. Results: The basaloid component of BSCC showed a growth advantage in the subcutaneous location and formed a mainly aneuploid population (69.3%) without any sign of invasiveness. However the transplantation of this tumour into the oral submucosa resulted in the reappearance of the squamous carcinoma cell population containing diploid and aneuploid cells in equal proportion. The diploid cells in the tumour growing in the subcutis were in G1 phase, whereas 30% of the diploid and aneuploid cells growing in the oral submucosa were in the growing (S + G2) phases of the cell cycle. The mixed tumour cell population in the oral submucosa produced 92-kDa collagenase IV, indicating a potential to infiltrate surrounding tissues. Conclusions: The biological behaviour of a human oral carcinoma (BSCC) in a xenograft model depends on the site of the transplantation. The aggressive malignancy of BSCC may be associated with the capacity of the basaloid cell population to generate squamous cells that are able to produce the 92-kDa type of collagenases in an appropriate microenvironment.

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalJournal of Cancer Research and Clinical Oncology
Volume125
Issue number1
DOIs
Publication statusPublished - 1999

Fingerprint

Squamous Cell Carcinoma
Aneuploidy
Collagenases
Growth
Diploidy
Population
Neoplasms
Transplantation
Epithelial Cells
Ploidies
G2 Phase
G1 Phase
S Phase
Heterografts
Cell Cycle
Carcinoma

Keywords

  • Collagenase
  • Growth parameters
  • Mixed tumours
  • Ploidy
  • Site dependence

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The site-dependent growth characteristics of a human xenotransplanted basaloid squamous cell carcinoma. / Babó, I.; Bocsi, J.; Jeney, A.

In: Journal of Cancer Research and Clinical Oncology, Vol. 125, No. 1, 1999, p. 35-41.

Research output: Contribution to journalArticle

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abstract = "Purpose: To improve our understanding of the aggressive behaviour of basaloid squamous cell carcinoma (BSCC) certain biological features related to malignancy were compared in the basaloid and in the squamous cell population of this tumour. Methods: Growth rate, cell population kinetics parameters, ploidy and collagenase activity were measured in BSCC xenotransplanted subcutaneously or into oral submucosa. Results: The basaloid component of BSCC showed a growth advantage in the subcutaneous location and formed a mainly aneuploid population (69.3{\%}) without any sign of invasiveness. However the transplantation of this tumour into the oral submucosa resulted in the reappearance of the squamous carcinoma cell population containing diploid and aneuploid cells in equal proportion. The diploid cells in the tumour growing in the subcutis were in G1 phase, whereas 30{\%} of the diploid and aneuploid cells growing in the oral submucosa were in the growing (S + G2) phases of the cell cycle. The mixed tumour cell population in the oral submucosa produced 92-kDa collagenase IV, indicating a potential to infiltrate surrounding tissues. Conclusions: The biological behaviour of a human oral carcinoma (BSCC) in a xenograft model depends on the site of the transplantation. The aggressive malignancy of BSCC may be associated with the capacity of the basaloid cell population to generate squamous cells that are able to produce the 92-kDa type of collagenases in an appropriate microenvironment.",
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AB - Purpose: To improve our understanding of the aggressive behaviour of basaloid squamous cell carcinoma (BSCC) certain biological features related to malignancy were compared in the basaloid and in the squamous cell population of this tumour. Methods: Growth rate, cell population kinetics parameters, ploidy and collagenase activity were measured in BSCC xenotransplanted subcutaneously or into oral submucosa. Results: The basaloid component of BSCC showed a growth advantage in the subcutaneous location and formed a mainly aneuploid population (69.3%) without any sign of invasiveness. However the transplantation of this tumour into the oral submucosa resulted in the reappearance of the squamous carcinoma cell population containing diploid and aneuploid cells in equal proportion. The diploid cells in the tumour growing in the subcutis were in G1 phase, whereas 30% of the diploid and aneuploid cells growing in the oral submucosa were in the growing (S + G2) phases of the cell cycle. The mixed tumour cell population in the oral submucosa produced 92-kDa collagenase IV, indicating a potential to infiltrate surrounding tissues. Conclusions: The biological behaviour of a human oral carcinoma (BSCC) in a xenograft model depends on the site of the transplantation. The aggressive malignancy of BSCC may be associated with the capacity of the basaloid cell population to generate squamous cells that are able to produce the 92-kDa type of collagenases in an appropriate microenvironment.

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