A sebgyógyulás és a tumorprogresszió mechanizmusának közös lépései. Irodalmi áttekintés egy kutyaharapás sebében kialakult colonadenocarcinoma metasztázis esete kapcsá

Translated title of the contribution: The similarities between the mechanism of wound healing and tumor development a - Review on the occasion of a patient with colonic adenocarcinoma metastasis in a dog-bite wound

Zoltán Mátrai, Gábor Péley, Vámos Ferenc Rényi, Emil Farkas, Tibor Kovács, István Köves

Research output: Contribution to journalReview article

3 Citations (Scopus)


For more than a century, the role of wound healing in the growth of tumours has been implied based on observations in experimental and clinical studies. In the recent 10-15 years processes such as cell adhesion, angiogenesis, metastatic cascade and growth factors (fe: EGF, TGF-CC, TGF-β, IGF-1, IGF-II, PDGF) have been identified to play keyrole in different stages of wound healing as well as in tumor progression. Experimental and clinical studies have established that wound healing creates a suitable environment favouring tumour growth and metastatic potential. Based on these observations, the clinical relevance of surgical procedures comes up, may playing a role in tumor recurrence after primary resection for cancer. This makes the opportunity of the development of completely new targeted approaches (antiangiogenic therapy, dormancy therapy) for the treatment of cancer. This review article is based on a case report of a 63-year-old female patient who had colonic adenocarcinoma metastasis of the hand after biting by a dog.

Original languageHungarian
Pages (from-to)99-109
Number of pages11
JournalOrvosi hetilap
Issue number3
Publication statusPublished - Dec 1 2005


ASJC Scopus subject areas

  • Medicine(all)

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