The significance of the calcium signal in the outer hair cells and its possible role in tinnitus of cochlear origin

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9 Citations (Scopus)

Abstract

Finely tuned changes in intracellular Ca2+ concentration modulate a variety of cellular functions in eukaryotic cells. The cytosolic Ca2+ concentration is also tightly controlled in the outer hair cells (OHCs), the highly specialized receptor and effector cells in the mammalian auditory epithelium, which are responsible for high sensitivity and sharp frequency discrimination in hearing. OHCs possess a complex system of transporters, pumps, exchangers, channels and binding proteins to develop and to halt the regulatory Ca2+ signal. The crucial role of elevated intracellular Ca2+ concentration in OHCs is to increase the efficacy of the electromechanical (electromotile) feedback via remodeling of the cortical cytoskeleton. Anomalies in the Ca2+ signaling pathway may lead to hypersensitivity of the cochlear amplifier and subsequently trigger tinnitus of cochlear origin. This review describes the dynamics of Ca2+ signaling in the OHCs and a model that may convey a putative mechanism of development of subjective idiopathic cochlear tinnitus.

Original languageEnglish
Pages (from-to)517-525
Number of pages9
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume261
Issue number10
DOIs
Publication statusPublished - Nov 2004

Fingerprint

Outer Auditory Hair Cells
Tinnitus
Cochlea
Calcium
Eukaryotic Cells
Cytoskeleton
Hearing
Carrier Proteins
Hypersensitivity
Epithelium

Keywords

  • Auditory processing
  • Calcium homeostasis
  • Calcium signaling
  • Cochlear amplifier
  • Electromotility
  • Outer hair cells
  • Tinnitus

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

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abstract = "Finely tuned changes in intracellular Ca2+ concentration modulate a variety of cellular functions in eukaryotic cells. The cytosolic Ca2+ concentration is also tightly controlled in the outer hair cells (OHCs), the highly specialized receptor and effector cells in the mammalian auditory epithelium, which are responsible for high sensitivity and sharp frequency discrimination in hearing. OHCs possess a complex system of transporters, pumps, exchangers, channels and binding proteins to develop and to halt the regulatory Ca2+ signal. The crucial role of elevated intracellular Ca2+ concentration in OHCs is to increase the efficacy of the electromechanical (electromotile) feedback via remodeling of the cortical cytoskeleton. Anomalies in the Ca2+ signaling pathway may lead to hypersensitivity of the cochlear amplifier and subsequently trigger tinnitus of cochlear origin. This review describes the dynamics of Ca2+ signaling in the OHCs and a model that may convey a putative mechanism of development of subjective idiopathic cochlear tinnitus.",
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KW - Calcium homeostasis

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