The significance of micro- and macrovascular biomarkers on cardiovascular outcome in chronic kidney disease: A prospective cohort study

O. Cseprekál, J. Egresits, Tabák, J. Nemcsik, Z. Járai, L. Babos, E. Fodor, K. Farkas, G. Godina, K. I. Kárpáthi, L. Kerkovits, A. Marton, Z. Nemcsik-Bencze, Z. Németh, L. Sallai, I. Kiss, A. Tislér

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Abstract

Measures of small and large artery dysfunction have not been investigated in a single cohort for the prediction of cardiovascular (CV) events in patients with nondialysed (ND) chronic kidney disease (CKD). This prospective cohort study aimed to determine whether central pulse wave velocity (cPWV), central pulse pressure (CPP) or microvascular post-occlusive reactive hyperaemia area (PORH HA) independently predict CV events and mortality in CKD-ND. A total of 94 stage 1-5 CKD-ND (65.3±13.1 years; estimated glomerular filtration rate 35.3 (22.8-49.4) ml min -1 per 1.73 m 2) patients were followed-up for a median of 52 (36-65) months and had baseline cPWV and CPP measured by applanation tonometry and PORH HA by laser Doppler flowmetry. Multiple failure time Cox regression models were used to determine the predictive role of vascular parameters on CV mortality and events. Based on multiple linear regressions, baseline age, diabetes, CV disease, and systolic blood pressure (SBP) were independently related to cPWV (R 2 =0.3), SBP and PORH HA to CPP (R 2 =0.45), whereas CPP was the only parameter independently related to PORH HA (R 2 =0.16, all P<0.05). During follow-up, 41 CV events occurred (14 CV deaths). In univariate analyses, cPWV (1.07 (1.02-1.13) per m s -1), CPP (1.04 (1.01-1.07) per mm Hg) and lnPORH HA (0.70 (0.58-0.85) per ln(PU × s)) were all related to the outcome. Baseline diabetes (HR 3.07 (1.65-5.68)), lnFGF23 (fibroblast growth factor-23; 1.86 (1.13-3.06) per RU ml -1) and CPP (1.04 (1.01-1.07) per mm Hg) were independent predictors of CV events. The impaired pulsatile component of large arteries (CPP) independently of other vascular markers (cPWV, PORH HA) predicted CV outcomes in CKD-ND. CPP may integrate the information provided by cPWV and PORH HA.

Original languageEnglish
Pages (from-to)449-455
Number of pages7
JournalJournal of Human Hypertension
Volume30
Issue number7
DOIs
Publication statusPublished - Jul 1 2016

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ASJC Scopus subject areas

  • Internal Medicine

Cite this

Cseprekál, O., Egresits, J., Tabák, Nemcsik, J., Járai, Z., Babos, L., Fodor, E., Farkas, K., Godina, G., Kárpáthi, K. I., Kerkovits, L., Marton, A., Nemcsik-Bencze, Z., Németh, Z., Sallai, L., Kiss, I., & Tislér, A. (2016). The significance of micro- and macrovascular biomarkers on cardiovascular outcome in chronic kidney disease: A prospective cohort study. Journal of Human Hypertension, 30(7), 449-455. https://doi.org/10.1038/jhh.2015.96