Az epidermális növekedési faktor receptor jelátviteli útjai és molekuláris biológiája

Translated title of the contribution: The signal transduction and molecular biology of epidermal growth factor

Pintér Ferenc, Varkondi Edit, Barti Juhász Helga, Árvai Kristóf, A. Lőrincz, Orfi Zoltán, I. Peták

Research output: Contribution to journalArticle

Abstract

The epidermal growth factor receptor (EGFR) and its signal transduction pathways inducing proliferation and inhibiting apoptosis play a pivotal role in the biology of epidermal human cancers including non-small cell lung cancer, colon cancer, breast cancer, and head and neck cancers. Small molecule tyrosin kinase inhibitors and monoclonal antibody therapeutics targeting EGFR are the most frequently used molecular targeted drugs currently in clinical use. Detailed knowledge of the biological significance of EGFR gene mutations and the molecular regulation of the EGFR-activated signal transduction pathways is important in all tumour types to understand the molecular mechanism of action of EGFR-inhibitors and their molecular diagnostics based personalized clinical use.

Original languageHungarian
Pages (from-to)163-170
Number of pages8
JournalOrvoskepzes
Volume84
Issue number3
Publication statusPublished - 2009

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Epidermal Growth Factor Receptor
Epidermal Growth Factor
Molecular Biology
Signal Transduction
Head and Neck Neoplasms
Colonic Neoplasms
Breast Neoplasms
erbB-1 Genes
Molecular Pathology
Non-Small Cell Lung Carcinoma
Neoplasms
Phosphotransferases
Monoclonal Antibodies
Apoptosis
Mutation
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ferenc, P., Edit, V., Helga, B. J., Kristóf, Á., Lőrincz, A., Zoltán, O., & Peták, I. (2009). Az epidermális növekedési faktor receptor jelátviteli útjai és molekuláris biológiája. Orvoskepzes, 84(3), 163-170.

Az epidermális növekedési faktor receptor jelátviteli útjai és molekuláris biológiája. / Ferenc, Pintér; Edit, Varkondi; Helga, Barti Juhász; Kristóf, Árvai; Lőrincz, A.; Zoltán, Orfi; Peták, I.

In: Orvoskepzes, Vol. 84, No. 3, 2009, p. 163-170.

Research output: Contribution to journalArticle

Ferenc, P, Edit, V, Helga, BJ, Kristóf, Á, Lőrincz, A, Zoltán, O & Peták, I 2009, 'Az epidermális növekedési faktor receptor jelátviteli útjai és molekuláris biológiája', Orvoskepzes, vol. 84, no. 3, pp. 163-170.
Ferenc P, Edit V, Helga BJ, Kristóf Á, Lőrincz A, Zoltán O et al. Az epidermális növekedési faktor receptor jelátviteli útjai és molekuláris biológiája. Orvoskepzes. 2009;84(3):163-170.
Ferenc, Pintér ; Edit, Varkondi ; Helga, Barti Juhász ; Kristóf, Árvai ; Lőrincz, A. ; Zoltán, Orfi ; Peták, I. / Az epidermális növekedési faktor receptor jelátviteli útjai és molekuláris biológiája. In: Orvoskepzes. 2009 ; Vol. 84, No. 3. pp. 163-170.
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