The serine protease granzyme M is preferentially expressed in NK-cell, γδ T-cell, and intestinal T-cell lymphomas

Evidence of origin from lymphocytes involved in innate immunity

L. Krenács, Mark J. Smyth, E. Bagdi, T. Krenács, L. Kópper, Thomas Rudiger, Andreas Zettl, Hans Konrad Muller-Hermelink, Elaine S. Jaffe, Mark Raffeld

Research output: Contribution to journalArticle

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Abstract

Granzyme M (GM) is a novel serine protease whose expression is highly restricted to natural killer (NK) cells, CD3+CD56+ T cells, and γδ T cells. Using a GM-specific monoclonal antibody, we analyzed the expression of GM in 214 mature T-cell and NK-cell lymphomas. GM was preferentially expressed in nasal NK/T-cell lymphomas (100%), γδ T-cell lymphomas (100%), and intestinal T-cell lymphomas (85%). In contrast, GM expression was present at low prevalence in mycosis fungoides/Sézary syndrome (3%), anaplastic large-cell lymphoma (6%), panniculitis-like T-cell lymphoma (11%), and angioimmunoblastic T-cell lymphoma (0%) cases. Peripheral T-cell lymphomas of unspecified subtype showed an intermediate frequency (37%) of GM expression, consistent with their heterogeneous origin. We conclude that GM expression is a distinctive feature of the nasal NK/T-cell, γδ T-cell, and intestinal T-cell lymphomas, and suggest that these tumors develop from lymphocytes involved in innate immunity.

Original languageEnglish
Pages (from-to)3590-3593
Number of pages4
JournalBlood
Volume101
Issue number9
DOIs
Publication statusPublished - May 1 2003

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Granzymes
T-cells
Lymphocytes
T-Cell Lymphoma
Serine Proteases
Innate Immunity
Natural Killer Cells
T-Lymphocytes
Natural Killer T-Cells
Nose
Peripheral T-Cell Lymphoma
Panniculitis
Anaplastic Large-Cell Lymphoma
Mycosis Fungoides
Lymphoma
Monoclonal Antibodies
Tumors

ASJC Scopus subject areas

  • Hematology

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The serine protease granzyme M is preferentially expressed in NK-cell, γδ T-cell, and intestinal T-cell lymphomas : Evidence of origin from lymphocytes involved in innate immunity. / Krenács, L.; Smyth, Mark J.; Bagdi, E.; Krenács, T.; Kópper, L.; Rudiger, Thomas; Zettl, Andreas; Muller-Hermelink, Hans Konrad; Jaffe, Elaine S.; Raffeld, Mark.

In: Blood, Vol. 101, No. 9, 01.05.2003, p. 3590-3593.

Research output: Contribution to journalArticle

Krenács, L. ; Smyth, Mark J. ; Bagdi, E. ; Krenács, T. ; Kópper, L. ; Rudiger, Thomas ; Zettl, Andreas ; Muller-Hermelink, Hans Konrad ; Jaffe, Elaine S. ; Raffeld, Mark. / The serine protease granzyme M is preferentially expressed in NK-cell, γδ T-cell, and intestinal T-cell lymphomas : Evidence of origin from lymphocytes involved in innate immunity. In: Blood. 2003 ; Vol. 101, No. 9. pp. 3590-3593.
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