The search for ideal antidote treatment in Gramoxone® intoxication

Katalin Barabás, L. Szabó, B. Matkovics

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

1. 1. The herbicide Gramoxone® (the active ingredient is paraquat) actively accumulates in the lung in the mammalian organism, where it exerts its toxic effect through the generation of oxygen radicals. 2. 2. Efforts were made to counteract the toxic effect in experiments in mice. 3. 3. Its penetration into the cells was blocked with the diamines putrescine and cadaverine. 4. 4. The synthesis of the prostaglandins, which are supposed by responsible for the acute symptoms, was inhibited with Aspisol®. 5. 5. Accumulation inhibition with biogenic amines is considered the most effective.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalGeneral Pharmacology
Volume18
Issue number2
DOIs
Publication statusPublished - 1987

Fingerprint

Antidotes
Paraquat
Poisons
Cadaverine
Cohort Effect
Biogenic Amines
Diamines
Putrescine
Herbicides
Prostaglandins
Reactive Oxygen Species
Lung
acetylsalicylic acid lysinate

ASJC Scopus subject areas

  • Pharmacology

Cite this

The search for ideal antidote treatment in Gramoxone® intoxication. / Barabás, Katalin; Szabó, L.; Matkovics, B.

In: General Pharmacology, Vol. 18, No. 2, 1987, p. 129-132.

Research output: Contribution to journalArticle

Barabás, Katalin ; Szabó, L. ; Matkovics, B. / The search for ideal antidote treatment in Gramoxone® intoxication. In: General Pharmacology. 1987 ; Vol. 18, No. 2. pp. 129-132.
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