The schizophrenic brain: A broken hermeneutic circle. Some new insights and results

Péter Érdi, Mihály Bányai, Balázs Ujfalussy, Vaibhav Diwadkar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Schizophrenia is often regarded as a set of symptoms caused by impairments in the cognitive control in macro-networks of the brain. To investigate this hypothesis, an fMRI study involving an associative learning task was conducted with schizophrenia patients and controls. A set of generative models of the BOLD signal generation were defined to describe the interaction of five brain regions (Primary Visual Cortex, Superior Parietal and Inferior Temporal Cortex, Hippocampus and Dorsal Prefrontal Cortex) and the experimental conditions. The models were fitted to the data using Bayesian model inversion. The comparison of different model connectivity structures lead to the finding that in schizophrenia, there are significant impairments in backward connections from prefrontal cortex to hippocampal and temporal regions in patients. These findings fit very well with the predictions of a neuron network model of encoding-recall switching dynamics we have described previously.

Original languageEnglish
Title of host publication2011 International Joint Conference on Neural Networks, IJCNN 2011 - Final Program
Pages3024-3027
Number of pages4
DOIs
Publication statusPublished - Oct 24 2011
Event2011 International Joint Conference on Neural Network, IJCNN 2011 - San Jose, CA, United States
Duration: Jul 31 2011Aug 5 2011

Publication series

NameProceedings of the International Joint Conference on Neural Networks

Other

Other2011 International Joint Conference on Neural Network, IJCNN 2011
CountryUnited States
CitySan Jose, CA
Period7/31/118/5/11

ASJC Scopus subject areas

  • Software
  • Artificial Intelligence

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    Érdi, P., Bányai, M., Ujfalussy, B., & Diwadkar, V. (2011). The schizophrenic brain: A broken hermeneutic circle. Some new insights and results. In 2011 International Joint Conference on Neural Networks, IJCNN 2011 - Final Program (pp. 3024-3027). [6033619] (Proceedings of the International Joint Conference on Neural Networks). https://doi.org/10.1109/IJCNN.2011.6033619