The rs13388259 intergenic polymorphism in the genomic context of the BCYRN1 gene is associated with Parkinson's disease in the hungarian population

Sándor Márki, Anikó Göblös, Eszter Szlávicz, Nóra Török, Péter Balicza, B. Bereznai, Annamária Takáts, J. Engelhardt, P. Klivényi, L. Vécsei, Mária Judit Molnár, N. Nagy, M. Széll

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by bradykinesia, resting tremor, and muscle rigidity. To date, approximately 50 genes have been implicated in PD pathogenesis, including both Mendelian genes with rare mutations and low-penetrance genes with common polymorphisms. Previous studies of low-penetrance genes focused on protein-coding genes, and less attention was given to long noncoding RNAs (lncRNAs). In this study, we aimed to investigate the susceptibility roles of lncRNA gene polymorphisms in the development of PD. Therefore, polymorphisms (n=15) of the PINK1-AS, UCHL1-AS, BCYRN1, SOX2-OT, ANRIL and HAR1A lncRNAs genes were genotyped in Hungarian PD patients (n=160) and age-And sex-matched controls (n=167). The rare allele of the rs13388259 intergenic polymorphism, located downstream of the BCYRN1 gene, was significantly more frequent among PD patients than control individuals (OR = 2.31; p=0.0015). In silico prediction suggested that this polymorphism is located in a noncoding region close to the binding site of the transcription factor HNF4A, which is a central regulatory hub gene that has been shown to be upregulated in the peripheral blood of PD patients. The rs13388259 polymorphism may interfere with the binding affinity of transcription factor HNF4A, potentially resulting in abnormal expression of target genes, such as BCYRN1.

Original languageEnglish
Article number9351598
JournalParkinson's Disease
Volume2018
DOIs
Publication statusPublished - Jan 1 2018

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Parkinson Disease
Long Noncoding RNA
Population
Genes
Penetrance
Transcription Factors
Muscle Rigidity
Hypokinesia
Hematologic Diseases
Tremor
Regulator Genes
Neurodegenerative Diseases
Computer Simulation
Alleles
Binding Sites
Gene Expression
Mutation
Proteins

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

The rs13388259 intergenic polymorphism in the genomic context of the BCYRN1 gene is associated with Parkinson's disease in the hungarian population. / Márki, Sándor; Göblös, Anikó; Szlávicz, Eszter; Török, Nóra; Balicza, Péter; Bereznai, B.; Takáts, Annamária; Engelhardt, J.; Klivényi, P.; Vécsei, L.; Molnár, Mária Judit; Nagy, N.; Széll, M.

In: Parkinson's Disease, Vol. 2018, 9351598, 01.01.2018.

Research output: Contribution to journalArticle

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AU - Török, Nóra

AU - Balicza, Péter

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AU - Engelhardt, J.

AU - Klivényi, P.

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