The route of antigen delivery determines the airway and lung tissue mechanical responses in allergic rats

G. L. Hall, F. Peták, C. McMenamin, P. D. Sly

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Previous results have shown tissue constriction in allergic animals following inhalation of an antigen. Further studies have demonstrated a differing response pattern in airway and parenchymal mechanics following inhaled (i.h.) or intravenous (i.v.) delivery of methacholine (MCh). Objective: The purpose of this study was to compare the acute allergic response in airway and parenchymal mechanics following i.h. and i.v. antigen challenge. Methods: Brown Norway rats were sensitized to ovalbumin (OVA). Rats were anaesthetized, paralysed, and thoracotomized, and lung input impedance (ZL) between 0.5 and 21 Hz was measured using small-amplitude pseudo-random oscillations at control, after saline, and for up to 1 h after either i.h. (n = 7) or i.v. (n = 5) administration of OVA. ZL was evaluated in terms of airway resistance (Raw) and inertante (law), and a constant phase tissue parenchymal damping (G) and elastance (H). Results: Following i.h. OVA challenge elevations were found in Raw [192 ± 32 (SE)%], G (223 ± 21%), and H (141 ± 5%). Raw showed higher elevation after i.v. challenge (418 ± 57%), whereas the elevation in G (278 ± 30%) and H (130 ± 4%) was approximately equal to those seen following inhalation of an antigen. Conclusions: Delivery (i.v.) of an antigen produces a significantly higher response in airway resistance, whereas inhaled antigen results in a mixed airway and parenchymal response.

Original languageEnglish
Pages (from-to)562-568
Number of pages7
JournalClinical and Experimental Allergy
Volume29
Issue number4
DOIs
Publication statusPublished - Apr 26 1999

Keywords

  • Acute allergic response
  • Airway mechanics
  • Forced oscillations
  • Pulmonary mechanics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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