The roles of platelet function, thromboxane, blood lipids and nitric oxide in hypertension of children and adolescents

C. Bereczki, S. Túr, I. Németh, É Sallai, Cs Torday, E. Nagy, I. Haszon, F. Papp

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The roles of platelet function, plasma lipids and nitric oxide (NO) were studied in adolescent patients with essential hypertension (JEHT group), with chronic renal failure (CRF) associated with hypertension (CRFH group), and CRF patients with normal blood pressure (CRF group), as compared with normal controls (cont. group). Platelet aggregation and the thromboxane B2 (TxB2) level were significantly higher in the JEHT and CRFH groups as compared with the cont. group, whereas they were significantly lower in the CRF group. On the other hand, the platelet cAMP level was significantly lower in the JEHT and CRFH groups than in the cont. group. The plasma NO level was significantly higher only in the JEHT as compared with the cont. group (120 ± 39 and 89 ± 21 uM, respectively). The plasma total cholesterol, triglyceride and LDL cholesterol concentrations were normal in the JEHT group, but high in the CRF and CRFH group, the HDL cholesterol level was lower in the CRF and CRFH groups as compared with the cont. and JEHT groups. There was a positive correlation between the platelet aggregation and the TxB2 level and between the BP and the platelet aggregation. In conclusion, hyperlipidaemia is commonly present in uraemia with haemodialysis, but is not specific for hypertension in children, while an increased platelet function is frequently associated with hypertension. The increased NO level might play a compensatory role in JEHT. (C) 2000 Harcourt Publishers Ltd.

Original languageEnglish
Pages (from-to)293-297
Number of pages5
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume62
Issue number5
DOIs
Publication statusPublished - 2000

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Thromboxanes
Platelets
Chronic Kidney Failure
Nitric Oxide
Blood
Blood Platelets
Hypertension
Lipids
Platelet Aggregation
Thromboxane B2
Agglomeration
Plasmas
Uremia
Blood pressure
Hyperlipidemias
LDL Cholesterol
HDL Cholesterol
Renal Dialysis
Triglycerides
Cholesterol

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

The roles of platelet function, thromboxane, blood lipids and nitric oxide in hypertension of children and adolescents. / Bereczki, C.; Túr, S.; Németh, I.; Sallai, É; Torday, Cs; Nagy, E.; Haszon, I.; Papp, F.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 62, No. 5, 2000, p. 293-297.

Research output: Contribution to journalArticle

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