The role of zeta potential in the stability of albendazole suspensions

E. J. Biró, I. Rácz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Interactions between active ingredients and various auxiliaries often occur in drug formulations. The consequences of these interactions are not only physical and chemical, but in many cases the liberation and resorption of the active ingredient are also altered. Therefore, these interactions are worth appropriate regard. One of the most important factors which has a high influence on the stability and drug dissolution of the suspensions is the viscosity-enhancing macromolecule. Our aim was to study the stabilization and drug dissolution of albendazole containing suspensions stabilized by carboxymethyl cellulose sodium, plotted against pH and a mixture of various electrolytes. Since zeta potential is a good reflection of the result of interactions occurring in the different formulations, in the present work the stability of the formulated systems is described with the zeta potential values.

Original languageEnglish
Pages (from-to)311-315
Number of pages5
JournalS.T.P. Pharma Sciences
Volume8
Issue number5
Publication statusPublished - Sep 1 1998

Keywords

  • Albendazole
  • Carboxymethyl cellulose sodium
  • Drug dissolution
  • Electrical double layer
  • Suspension
  • Zeta potential

ASJC Scopus subject areas

  • Pharmaceutical Science

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