The role of vasopressin in hypothalamo-pituitary-adrenal axis activation during stress: An assessment of the evidence

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Abstract

The hypothalamo-pituitary-adrenal (HPA) axis is a key component of the stress reaction. Most contemporary reviews mention the corticotropin-releasing hormone and arginine vasopressin (AVP)-containing parvocellular neurons of the hypothalamic paraventricular nucleus as the endocrinomotor component of the system. Although there are many studies about the role of AVP in the stress activation, there is evidence consistent and inconsistent with the general view on the importance of AVP. We propose a list of experiments that may provide critical evidence for or against the widely held opinion. The naturally AVP-deficient Brattleboro rat seems to be a good tool for studying the role of AVP. Our experiments on Brattleboro rats with restraint and ip hypertonic saline injection did not support the prominent role of AVP in acute stress, although in forced swim the lack of AVP influenced the HPA axis activation. Among different chronic stress situations (14 days' restraint, chronic morphine or ip hypertonic saline treatment, streptozotocin-induced diabetes mellitus), the role of AVP was not confirmed by changes in somatic parameter (i.e., body, thymus, and adrenal weight changes).

Original languageEnglish
Pages (from-to)151-161
Number of pages11
JournalAnnals of the New York Academy of Sciences
Volume1018
DOIs
Publication statusPublished - 2004

Fingerprint

Arginine Vasopressin
Vasopressins
Chemical activation
Brattleboro Rats
Rats
Thymus
Experimental Diabetes Mellitus
Activation
Paraventricular Hypothalamic Nucleus
Corticotropin-Releasing Hormone
Streptozocin
Medical problems
Thymus Gland
Morphine
Neurons
Diabetes Mellitus
Experiments
Weights and Measures
Injections
Rat

Keywords

  • Acute stress
  • Adrenocorticotropic hormone
  • AVP
  • Brattleboro rat
  • Chronic stress
  • Corticotropin-releasing hormone
  • Diabetes mellitus
  • Forced swim
  • Hypertonic saline
  • Morphine injection
  • Restraint
  • Streptozotocin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "The role of vasopressin in hypothalamo-pituitary-adrenal axis activation during stress: An assessment of the evidence",
abstract = "The hypothalamo-pituitary-adrenal (HPA) axis is a key component of the stress reaction. Most contemporary reviews mention the corticotropin-releasing hormone and arginine vasopressin (AVP)-containing parvocellular neurons of the hypothalamic paraventricular nucleus as the endocrinomotor component of the system. Although there are many studies about the role of AVP in the stress activation, there is evidence consistent and inconsistent with the general view on the importance of AVP. We propose a list of experiments that may provide critical evidence for or against the widely held opinion. The naturally AVP-deficient Brattleboro rat seems to be a good tool for studying the role of AVP. Our experiments on Brattleboro rats with restraint and ip hypertonic saline injection did not support the prominent role of AVP in acute stress, although in forced swim the lack of AVP influenced the HPA axis activation. Among different chronic stress situations (14 days' restraint, chronic morphine or ip hypertonic saline treatment, streptozotocin-induced diabetes mellitus), the role of AVP was not confirmed by changes in somatic parameter (i.e., body, thymus, and adrenal weight changes).",
keywords = "Acute stress, Adrenocorticotropic hormone, AVP, Brattleboro rat, Chronic stress, Corticotropin-releasing hormone, Diabetes mellitus, Forced swim, Hypertonic saline, Morphine injection, Restraint, Streptozotocin",
author = "Makara, {G{\'a}bor B.} and Zsuzsa Mergl and D{\'o}ra Zelena",
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AB - The hypothalamo-pituitary-adrenal (HPA) axis is a key component of the stress reaction. Most contemporary reviews mention the corticotropin-releasing hormone and arginine vasopressin (AVP)-containing parvocellular neurons of the hypothalamic paraventricular nucleus as the endocrinomotor component of the system. Although there are many studies about the role of AVP in the stress activation, there is evidence consistent and inconsistent with the general view on the importance of AVP. We propose a list of experiments that may provide critical evidence for or against the widely held opinion. The naturally AVP-deficient Brattleboro rat seems to be a good tool for studying the role of AVP. Our experiments on Brattleboro rats with restraint and ip hypertonic saline injection did not support the prominent role of AVP in acute stress, although in forced swim the lack of AVP influenced the HPA axis activation. Among different chronic stress situations (14 days' restraint, chronic morphine or ip hypertonic saline treatment, streptozotocin-induced diabetes mellitus), the role of AVP was not confirmed by changes in somatic parameter (i.e., body, thymus, and adrenal weight changes).

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