The role of Vδ2+T-cells in patients with active Mycobacterium tuberculosis infection and tuberculin anergy

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Abstract

SETTING: Tuberculosis (TB) is one of the most common major infectious diseases. In humans, acquired protective immunity to Mycobacterium tuberculosis depends on T-cells and involves multiple T-cell subsets; however, the pathways used by T-cells to restrict the growth of M. tuberculosis are poorly understood. OBJECTIVE: To investigate the possible role of Vδ2+T-cells and regulatory T-cells in the immune response to M. tuberculosis. As Vδ2+T-cell function has been shown to be impaired in patients with M. tuberculosis infection, we investigated the percentage of perforin and Fas ligand (FasL) positive Vδ2+T-cells and the possible role of activating and inhibitory natural killer (NK) cell receptors as well as that of regulatory T-cells in the control of tuberculin responsiveness. RESULTS: Tuberculin-negative patients demonstrated decreased perforin expression and increased FasL expression, which could not be explained by dysregulation of NK cell receptor expression or altered regulatory T-cell function. CONCLUSION: Altered cytotoxic capacity and apoptotic potential of Vδ2+T-cells provide a plausible explanation for defective cellular immune functions in M. tuberculosis-infected anergic patients.

Original languageEnglish
Pages (from-to)262-268
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Volume12
Issue number3
Publication statusPublished - Mar 2008

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Mycobacterium Infections
Tuberculin
Mycobacterium tuberculosis
Natural Killer Cell Receptors
T-Lymphocytes
Regulatory T-Lymphocytes
Perforin
Fas Ligand Protein
T-Lymphocyte Subsets
Adaptive Immunity
Communicable Diseases
Tuberculosis
Growth

Keywords

  • Anergy
  • Human
  • Mycobacterium tuberculosis
  • NK cell receptors
  • Vδ2+T-cells

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

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title = "The role of Vδ2+T-cells in patients with active Mycobacterium tuberculosis infection and tuberculin anergy",
abstract = "SETTING: Tuberculosis (TB) is one of the most common major infectious diseases. In humans, acquired protective immunity to Mycobacterium tuberculosis depends on T-cells and involves multiple T-cell subsets; however, the pathways used by T-cells to restrict the growth of M. tuberculosis are poorly understood. OBJECTIVE: To investigate the possible role of Vδ2+T-cells and regulatory T-cells in the immune response to M. tuberculosis. As Vδ2+T-cell function has been shown to be impaired in patients with M. tuberculosis infection, we investigated the percentage of perforin and Fas ligand (FasL) positive Vδ2+T-cells and the possible role of activating and inhibitory natural killer (NK) cell receptors as well as that of regulatory T-cells in the control of tuberculin responsiveness. RESULTS: Tuberculin-negative patients demonstrated decreased perforin expression and increased FasL expression, which could not be explained by dysregulation of NK cell receptor expression or altered regulatory T-cell function. CONCLUSION: Altered cytotoxic capacity and apoptotic potential of Vδ2+T-cells provide a plausible explanation for defective cellular immune functions in M. tuberculosis-infected anergic patients.",
keywords = "Anergy, Human, Mycobacterium tuberculosis, NK cell receptors, Vδ2+T-cells",
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T1 - The role of Vδ2+T-cells in patients with active Mycobacterium tuberculosis infection and tuberculin anergy

AU - Szereday, L.

AU - Baliko, Z.

AU - Szekeres-Barthó, J.

PY - 2008/3

Y1 - 2008/3

N2 - SETTING: Tuberculosis (TB) is one of the most common major infectious diseases. In humans, acquired protective immunity to Mycobacterium tuberculosis depends on T-cells and involves multiple T-cell subsets; however, the pathways used by T-cells to restrict the growth of M. tuberculosis are poorly understood. OBJECTIVE: To investigate the possible role of Vδ2+T-cells and regulatory T-cells in the immune response to M. tuberculosis. As Vδ2+T-cell function has been shown to be impaired in patients with M. tuberculosis infection, we investigated the percentage of perforin and Fas ligand (FasL) positive Vδ2+T-cells and the possible role of activating and inhibitory natural killer (NK) cell receptors as well as that of regulatory T-cells in the control of tuberculin responsiveness. RESULTS: Tuberculin-negative patients demonstrated decreased perforin expression and increased FasL expression, which could not be explained by dysregulation of NK cell receptor expression or altered regulatory T-cell function. CONCLUSION: Altered cytotoxic capacity and apoptotic potential of Vδ2+T-cells provide a plausible explanation for defective cellular immune functions in M. tuberculosis-infected anergic patients.

AB - SETTING: Tuberculosis (TB) is one of the most common major infectious diseases. In humans, acquired protective immunity to Mycobacterium tuberculosis depends on T-cells and involves multiple T-cell subsets; however, the pathways used by T-cells to restrict the growth of M. tuberculosis are poorly understood. OBJECTIVE: To investigate the possible role of Vδ2+T-cells and regulatory T-cells in the immune response to M. tuberculosis. As Vδ2+T-cell function has been shown to be impaired in patients with M. tuberculosis infection, we investigated the percentage of perforin and Fas ligand (FasL) positive Vδ2+T-cells and the possible role of activating and inhibitory natural killer (NK) cell receptors as well as that of regulatory T-cells in the control of tuberculin responsiveness. RESULTS: Tuberculin-negative patients demonstrated decreased perforin expression and increased FasL expression, which could not be explained by dysregulation of NK cell receptor expression or altered regulatory T-cell function. CONCLUSION: Altered cytotoxic capacity and apoptotic potential of Vδ2+T-cells provide a plausible explanation for defective cellular immune functions in M. tuberculosis-infected anergic patients.

KW - Anergy

KW - Human

KW - Mycobacterium tuberculosis

KW - NK cell receptors

KW - Vδ2+T-cells

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