Az ultrahangvizsgálat szerepe a 18-as triszómia praenatalis diagnosztikájában: 70 Eset tapasztalatai

Translated title of the contribution: The role of ultrasonography in the prenatal diagnosis of trisomy 18, experiences with 70 cases

Csaba Papp, Artúr Beke, Zoltán Bán, Zsanett Szigeti, Erno Tóth-Pál, Ákos Csaba, József Gábor Joó, Zoltán Papp

Research output: Contribution to journalArticle

Abstract

We have investigated the role of second trimester ultrasound examination in the prenatal diagnosis of trisomy 18. Out of the 22,150 fetal chromosomal-analyses, 70 fetuses were found to have trisomy 18, between 1990-2004. Ultrasonographic findings of this aneuploidy are analysed. The average maternal age was 32.4 years, the average gestational period was 19.5 weeks. Major anomalies were found in 61 (87.1%) cases. Among them cardiac anomalies were the most frequent (47.1%) with a 27.1% rate of ventricular septal defects. Anomalies of the central nervous system were seen in 35.7% of the cases. Abnormal head shape was the most frequently detected anomaly in this group (12.9%). Fifty-six fetuses (80%) out of the seventy had at least one minor anomaly. Choroidal plexus cyst (CPC) was the most common finding (38.6%). Increased nuchal fold thickness was detected in 17.1% of the fetuses with trisomy 18. In the second trimester, vast majority of the fetuses with trisomy 18 have sonographically detectable abnormalities. Both the 87.1% frequency of major anomalies and the 80% frequency of minor anomalies are substantially higher than a multiple biochemical marker test could reach, so far. It has also been demonstrated, that fetal echocardiography plays a pivotal role in the diagnosis of trisomy 18.

Translated title of the contributionThe role of ultrasonography in the prenatal diagnosis of trisomy 18, experiences with 70 cases
Original languageHungarian
Pages (from-to)405-411
Number of pages7
JournalMagyar Noorvosok Lapja
Volume69
Issue number5
Publication statusPublished - Nov 17 2006

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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