The role of TTF-1 in differentiating primary and metastatic lung adenocarcinomas

Judit Moldvay, M. Jackel, K. Bogos, I. Soltész, L. Agócs, G. Kovács, Z. Schaff

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Thyroid transcription factor-1 (TTF-1) is a sensitive marker for pulmonary and thyroid adenocarcinomas. The aim of this work was to determine its usefulness in distinction between primary and metastatic lung adenocarcinomas. We have examined the expression of TTF-1 in 100 solitary pulmonary nodules. They included 50 stage I peripheral primary bronchial adenocarcinomas (30 men, 20 women, mean age: 60 years) and 50 metastatic pulmonary adenocarcinomas (21 men, 29 women, mean age: 57 years) of different origins, such as breast (13), colon (13), rectum (13), kidney (7), stomach (2), and thyroid gland (2). TTF-1 immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissues. In primary bronchial adenocarcinomas we found immunopositivity in 46/50 cases, among them 30 cases showed strong nuclear immunostaining. In four primary adenocarcinoma cases the observed immunopositivity was localized to the cytoplasm. Out of the metastatic adenocarcinomas all but the 2 thyroid cancers were negative. Both thyroid tumors showed strong immunopositivity. Our results confirm that TTF-1 immunohistochemistry is a very sensitive and highly specific method in the differential diagnosis of primary and metastatic lung adenocarcinomas and should be used in the everyday clinical practice.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalPathology and Oncology Research
Volume10
Issue number2
Publication statusPublished - 2004

Fingerprint

Adenocarcinoma
Thyroid Gland
Immunohistochemistry
Solitary Pulmonary Nodule
Thyroid Neoplasms
Rectum
Paraffin
Formaldehyde
Stomach
Colon
Cytoplasm
Breast
Differential Diagnosis
Kidney
Adenocarcinoma of lung
thyroid nuclear factor 1
Neoplasms

Keywords

  • Immunohistochemistry
  • Lung adenocarcinoma
  • Metastasis
  • TTF-1

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Moldvay, J., Jackel, M., Bogos, K., Soltész, I., Agócs, L., Kovács, G., & Schaff, Z. (2004). The role of TTF-1 in differentiating primary and metastatic lung adenocarcinomas. Pathology and Oncology Research, 10(2), 85-88.

The role of TTF-1 in differentiating primary and metastatic lung adenocarcinomas. / Moldvay, Judit; Jackel, M.; Bogos, K.; Soltész, I.; Agócs, L.; Kovács, G.; Schaff, Z.

In: Pathology and Oncology Research, Vol. 10, No. 2, 2004, p. 85-88.

Research output: Contribution to journalArticle

Moldvay, J, Jackel, M, Bogos, K, Soltész, I, Agócs, L, Kovács, G & Schaff, Z 2004, 'The role of TTF-1 in differentiating primary and metastatic lung adenocarcinomas', Pathology and Oncology Research, vol. 10, no. 2, pp. 85-88.
Moldvay J, Jackel M, Bogos K, Soltész I, Agócs L, Kovács G et al. The role of TTF-1 in differentiating primary and metastatic lung adenocarcinomas. Pathology and Oncology Research. 2004;10(2):85-88.
Moldvay, Judit ; Jackel, M. ; Bogos, K. ; Soltész, I. ; Agócs, L. ; Kovács, G. ; Schaff, Z. / The role of TTF-1 in differentiating primary and metastatic lung adenocarcinomas. In: Pathology and Oncology Research. 2004 ; Vol. 10, No. 2. pp. 85-88.
@article{c17af23bf9c744c0a185e01133dd2c2c,
title = "The role of TTF-1 in differentiating primary and metastatic lung adenocarcinomas",
abstract = "Thyroid transcription factor-1 (TTF-1) is a sensitive marker for pulmonary and thyroid adenocarcinomas. The aim of this work was to determine its usefulness in distinction between primary and metastatic lung adenocarcinomas. We have examined the expression of TTF-1 in 100 solitary pulmonary nodules. They included 50 stage I peripheral primary bronchial adenocarcinomas (30 men, 20 women, mean age: 60 years) and 50 metastatic pulmonary adenocarcinomas (21 men, 29 women, mean age: 57 years) of different origins, such as breast (13), colon (13), rectum (13), kidney (7), stomach (2), and thyroid gland (2). TTF-1 immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissues. In primary bronchial adenocarcinomas we found immunopositivity in 46/50 cases, among them 30 cases showed strong nuclear immunostaining. In four primary adenocarcinoma cases the observed immunopositivity was localized to the cytoplasm. Out of the metastatic adenocarcinomas all but the 2 thyroid cancers were negative. Both thyroid tumors showed strong immunopositivity. Our results confirm that TTF-1 immunohistochemistry is a very sensitive and highly specific method in the differential diagnosis of primary and metastatic lung adenocarcinomas and should be used in the everyday clinical practice.",
keywords = "Immunohistochemistry, Lung adenocarcinoma, Metastasis, TTF-1",
author = "Judit Moldvay and M. Jackel and K. Bogos and I. Solt{\'e}sz and L. Ag{\'o}cs and G. Kov{\'a}cs and Z. Schaff",
year = "2004",
language = "English",
volume = "10",
pages = "85--88",
journal = "Pathology and Oncology Research",
issn = "1219-4956",
publisher = "Springer Netherlands",
number = "2",

}

TY - JOUR

T1 - The role of TTF-1 in differentiating primary and metastatic lung adenocarcinomas

AU - Moldvay, Judit

AU - Jackel, M.

AU - Bogos, K.

AU - Soltész, I.

AU - Agócs, L.

AU - Kovács, G.

AU - Schaff, Z.

PY - 2004

Y1 - 2004

N2 - Thyroid transcription factor-1 (TTF-1) is a sensitive marker for pulmonary and thyroid adenocarcinomas. The aim of this work was to determine its usefulness in distinction between primary and metastatic lung adenocarcinomas. We have examined the expression of TTF-1 in 100 solitary pulmonary nodules. They included 50 stage I peripheral primary bronchial adenocarcinomas (30 men, 20 women, mean age: 60 years) and 50 metastatic pulmonary adenocarcinomas (21 men, 29 women, mean age: 57 years) of different origins, such as breast (13), colon (13), rectum (13), kidney (7), stomach (2), and thyroid gland (2). TTF-1 immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissues. In primary bronchial adenocarcinomas we found immunopositivity in 46/50 cases, among them 30 cases showed strong nuclear immunostaining. In four primary adenocarcinoma cases the observed immunopositivity was localized to the cytoplasm. Out of the metastatic adenocarcinomas all but the 2 thyroid cancers were negative. Both thyroid tumors showed strong immunopositivity. Our results confirm that TTF-1 immunohistochemistry is a very sensitive and highly specific method in the differential diagnosis of primary and metastatic lung adenocarcinomas and should be used in the everyday clinical practice.

AB - Thyroid transcription factor-1 (TTF-1) is a sensitive marker for pulmonary and thyroid adenocarcinomas. The aim of this work was to determine its usefulness in distinction between primary and metastatic lung adenocarcinomas. We have examined the expression of TTF-1 in 100 solitary pulmonary nodules. They included 50 stage I peripheral primary bronchial adenocarcinomas (30 men, 20 women, mean age: 60 years) and 50 metastatic pulmonary adenocarcinomas (21 men, 29 women, mean age: 57 years) of different origins, such as breast (13), colon (13), rectum (13), kidney (7), stomach (2), and thyroid gland (2). TTF-1 immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissues. In primary bronchial adenocarcinomas we found immunopositivity in 46/50 cases, among them 30 cases showed strong nuclear immunostaining. In four primary adenocarcinoma cases the observed immunopositivity was localized to the cytoplasm. Out of the metastatic adenocarcinomas all but the 2 thyroid cancers were negative. Both thyroid tumors showed strong immunopositivity. Our results confirm that TTF-1 immunohistochemistry is a very sensitive and highly specific method in the differential diagnosis of primary and metastatic lung adenocarcinomas and should be used in the everyday clinical practice.

KW - Immunohistochemistry

KW - Lung adenocarcinoma

KW - Metastasis

KW - TTF-1

UR - http://www.scopus.com/inward/record.url?scp=3142705737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3142705737&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 85

EP - 88

JO - Pathology and Oncology Research

JF - Pathology and Oncology Research

SN - 1219-4956

IS - 2

ER -